Pregledni rad

Osteoporosis in children with inflammatory bowel disease

Kristina Baraba Dekanić orcid.org/0000-0003-2720-6845 ; Klinika za pedijatriju, KBC Rijeka, Rijeka
Željka Crnčević-Orlić ; Klinika za internu medicinu, KBC Rijeka, Rijeka
Mladen Peršić ; Klinika za pedijatriju, KBC Rijeka, Rijeka

Sažetak

Inflammatory bowel disease (IBD) consists of Crohn disease, ulcerative colitis and
indeterminate colitis and 25 % of patients present before 20 years of age. Osteoporosis is a
well known complication of inflammatory bowel disease, the main clinically important manifestation
of which is fracture. In children and adults with inflammatory bowel disease the rate
of osteopenia and osteoporosis is up to 70 %. Bone mineral density is evaluated by quantitative
computed tomography, quantitative ultrasonography and dual-energy X-ray absorptiometry
(DEXA). Dual-energy X-ray absorptiometry is the „golden standard” in bone mineral density
evaluation. In children with IBD main causes of osteoporosis are malnutrition, corticosteroid
therapy and elevated levels of proinflammatory factors. The principles of osteoporosis treatment
in children are minimizing or eliminating changeable risk factors. These are adequate
calcium and vitamin D uptake according to the patient’s age, optimal body mass, adequate
exercise, and correction of hormonal imbalance and treatment of underlying disease. Pharmacotherapy
is used only when general measures were not successful, and only bisphosphonates
can be used in children. The approach to the pharmacotherapy is always individual.

Ključne riječi

children; dual-energy X-ray absorptiometry; inflammatory bowel disease; osteoporosis

Hrčak ID:

98603

URI

https://hrcak.srce.hr/98603

Datum izdavanja:

4.3.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.817 *