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Arhiv za higijenu rada i toksikologiju, Vol. 51 No. 4, 2000.

Stručni rad

Analysis of Drugs of Abuse in Urine by Gas Chromatography/Mass Spectrometry: Experience and Application

Višnja Karačić
Ljiljana Skender

Puni tekst: engleski, pdf (86 KB) str. 389-400 preuzimanja: 11.461* citiraj
APA 6th Edition
Karačić, V. i Skender, Lj. (2000). Analysis of Drugs of Abuse in Urine by Gas Chromatography/Mass Spectrometry: Experience and Application. Arhiv za higijenu rada i toksikologiju, 51 (4), 389-400. Preuzeto s https://hrcak.srce.hr/738
MLA 8th Edition
Karačić, Višnja i Ljiljana Skender. "Analysis of Drugs of Abuse in Urine by Gas Chromatography/Mass Spectrometry: Experience and Application." Arhiv za higijenu rada i toksikologiju, vol. 51, br. 4, 2000, str. 389-400. https://hrcak.srce.hr/738. Citirano 23.02.2019.
Chicago 17th Edition
Karačić, Višnja i Ljiljana Skender. "Analysis of Drugs of Abuse in Urine by Gas Chromatography/Mass Spectrometry: Experience and Application." Arhiv za higijenu rada i toksikologiju 51, br. 4 (2000): 389-400. https://hrcak.srce.hr/738
Harvard
Karačić, V., i Skender, Lj. (2000). 'Analysis of Drugs of Abuse in Urine by Gas Chromatography/Mass Spectrometry: Experience and Application', Arhiv za higijenu rada i toksikologiju, 51(4), str. 389-400. Preuzeto s: https://hrcak.srce.hr/738 (Datum pristupa: 23.02.2019.)
Vancouver
Karačić V, Skender Lj. Analysis of Drugs of Abuse in Urine by Gas Chromatography/Mass Spectrometry: Experience and Application. Arh Hig Rada Toksikol. [Internet]. 2000 [pristupljeno 23.02.2019.];51(4):389-400. Dostupno na: https://hrcak.srce.hr/738
IEEE
V. Karačić i Lj. Skender, "Analysis of Drugs of Abuse in Urine by Gas Chromatography/Mass Spectrometry: Experience and Application", Arhiv za higijenu rada i toksikologiju, vol.51, br. 4, str. 389-400, 2000. [Online]. Dostupno na: https://hrcak.srce.hr/738. [Citirano: 23.02.2019.]

Sažetak
This paper describes quantitative methods for determination of urinary drugs/metabolites. The analysis included indicators of opiate (morphine, codeine, 6-monoacetylmorphine) and methadone (methadone) consumption, indicator of marihuana/ hashish consumption (11-nor-9-tetrahydrocannabinol- 9-carboxylic acid), indicators of cocaine consumption (cocaine, benzoylecgonine, and ecgonine methyl ester) and of amphetamine consumption (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4- methylenedioxymethamphetamine, and 3,4- methylenedioxethylamphetamine). The methods included solid-phase extraction of urine, concentration of eluent, derivatisation, and quantitative analysis by gas chromatography/ mass spectrometry (GC/MS) on a capillary column in the electron impact and selected ion monitoring (SIM) mode. Sensitivity, reproducibility, and accuracy were determined for all analytes (limit of detection between 3 and 12 ng/ml, precision <10%, accuracy >92%). The accuracy was checked through analysis of standard reference materials and participation in an international quality assessment programme. The methods were used in the analysis of spot urine samples of 60 subjects suspected of drug abuse. Negative findings indicated several disadvantages of urine as a biological sample.

Ključne riječi
amphetamines; cocaine/metabolites; codeine; 6-monoacetylmorphine; methadone; morphine

Hrčak ID: 738

URI
https://hrcak.srce.hr/738

[hrvatski]

Posjeta: 13.361 *