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Gamma-Glutamyltransferase and C-Reactive Protein in Stable Chronic Obstructive Pulmonary Disease

Vanja Radisic Biljak ; University of Zagreb, »Merkur« University Hospital, University Department of Medical Biochemistry and Laboratory Medicine, Zagreb, Croatia
Lada Rumora ; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Zagreb, Croatia
Ivana Cepelak ; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Zagreb, Croatia
Dolores Pancirov ; »Dr. Ivo Pedi{i}« General Hospital, Department for Pulmology, Petrinja, Croatia
Sanja Popovic-Grle ; University of Zagreb, Zagreb University Hospital Center, »Jordanovac« University Hospital for Lung Diseases, School of Medicine, Zagreb, Croatia
Jasna Soric ; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Zagreb, Croatia
Gordana Stjepanovic ; »Dr. Ivo Pedi{i}« General Hospital, Department for Pulmology, Petrinja, Croatia
Tihana Zanic Grubisic ; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Zagreb, Croatia

Puni tekst: engleski, pdf (148 KB) str. 221-227 preuzimanja: 322* citiraj
APA 6th Edition
Radisic Biljak, V., Rumora, L., Cepelak, I., Pancirov, D., Popovic-Grle, S., Soric, J., ... Zanic Grubisic, T. (2013). Gamma-Glutamyltransferase and C-Reactive Protein in Stable Chronic Obstructive Pulmonary Disease. Collegium antropologicum, 37 (1), 221-227. Preuzeto s https://hrcak.srce.hr/99570
MLA 8th Edition
Radisic Biljak, Vanja, et al. "Gamma-Glutamyltransferase and C-Reactive Protein in Stable Chronic Obstructive Pulmonary Disease." Collegium antropologicum, vol. 37, br. 1, 2013, str. 221-227. https://hrcak.srce.hr/99570. Citirano 20.11.2019.
Chicago 17th Edition
Radisic Biljak, Vanja, Lada Rumora, Ivana Cepelak, Dolores Pancirov, Sanja Popovic-Grle, Jasna Soric, Gordana Stjepanovic i Tihana Zanic Grubisic. "Gamma-Glutamyltransferase and C-Reactive Protein in Stable Chronic Obstructive Pulmonary Disease." Collegium antropologicum 37, br. 1 (2013): 221-227. https://hrcak.srce.hr/99570
Harvard
Radisic Biljak, V., et al. (2013). 'Gamma-Glutamyltransferase and C-Reactive Protein in Stable Chronic Obstructive Pulmonary Disease', Collegium antropologicum, 37(1), str. 221-227. Preuzeto s: https://hrcak.srce.hr/99570 (Datum pristupa: 20.11.2019.)
Vancouver
Radisic Biljak V, Rumora L, Cepelak I, Pancirov D, Popovic-Grle S, Soric J i sur. Gamma-Glutamyltransferase and C-Reactive Protein in Stable Chronic Obstructive Pulmonary Disease. Collegium antropologicum [Internet]. 2013 [pristupljeno 20.11.2019.];37(1):221-227. Dostupno na: https://hrcak.srce.hr/99570
IEEE
V. Radisic Biljak, et al., "Gamma-Glutamyltransferase and C-Reactive Protein in Stable Chronic Obstructive Pulmonary Disease", Collegium antropologicum, vol.37, br. 1, str. 221-227, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/99570. [Citirano: 20.11.2019.]

Sažetak
Systemic inflammation and oxidative stress are the most important features of chronic obstructive pulmonary disease (COPD). The presence of oxidative stress in the airways of smokers, the largest population of COPD patients, is a consequence of direct inhalation of cigarette smoke and increased inflammation-related production of reactive oxygen species. On the other hand, oxidative stress appears to be the key component of many processes associated with chronic inflammation. We intend to examine whether serum C-reactive protein (CRP) concentration and gamma-glutamyltransferase (GGT) activity might be used as auxiliary markers in monitoring level of oxidative stress and inflammation in clinically stable COPD. We also investigated influence of cigarette smoking on these two systemic parameters. Catalytic activity of GGT and concentration of CRP were determined in sera of COPD patients (N=109) and in healthy controls (N=51) by
using standard spectrophotometric method and immunoturbidimetric method, respectively. Concentration of CRP and activity of GGT were increased in COPD patients, as compared to healthy controls (p<0.05). We found a significant positive correlation between those two parameters in COPD patients (r=0.202, p=0.0371). Our results showed no difference in GGT activity (p=0.606) or CRP concentration (p=0.573) between groups of patients when subdivided according to the
severity of the disease. Smoking did not have a significant impact on CRP and GGT values in COPD patients and healthy controls. We showed an increase of serum CRP and GGT values in COPD patients, and we suggest that serum GGT activity might also represent an inflammation/oxidative stress marker. It seems that COPD patients present higher serum CRP and GGT values than healthy subjects independently from their smoking habits.

Ključne riječi
chronic obstructive pulmonary disease; C-reactive protein; gamma-glutamyltransferase; smoking; systemic inflammation

Hrčak ID: 99570

URI
https://hrcak.srce.hr/99570

Posjeta: 581 *