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Arhiv za higijenu rada i toksikologiju, Vol. 51 No. 4, 2000.

Pregledni rad

Hair - Biological Sample for the Analysis of Drugs of Abuse

Ljiljana Skender

Puni tekst: hrvatski, pdf (103 KB) str. 409-420 preuzimanja: 6.340* citiraj
APA 6th Edition
Skender, Lj. (2000). Kosa - biološki uzorak za analizu droga. Arhiv za higijenu rada i toksikologiju, 51 (4), 409-420. Preuzeto s https://hrcak.srce.hr/747
MLA 8th Edition
Skender, Ljiljana. "Kosa - biološki uzorak za analizu droga." Arhiv za higijenu rada i toksikologiju, vol. 51, br. 4, 2000, str. 409-420. https://hrcak.srce.hr/747. Citirano 22.02.2019.
Chicago 17th Edition
Skender, Ljiljana. "Kosa - biološki uzorak za analizu droga." Arhiv za higijenu rada i toksikologiju 51, br. 4 (2000): 409-420. https://hrcak.srce.hr/747
Harvard
Skender, Lj. (2000). 'Kosa - biološki uzorak za analizu droga', Arhiv za higijenu rada i toksikologiju, 51(4), str. 409-420. Preuzeto s: https://hrcak.srce.hr/747 (Datum pristupa: 22.02.2019.)
Vancouver
Skender Lj. Kosa - biološki uzorak za analizu droga. Arh Hig Rada Toksikol. [Internet]. 2000 [pristupljeno 22.02.2019.];51(4):409-420. Dostupno na: https://hrcak.srce.hr/747
IEEE
Lj. Skender, "Kosa - biološki uzorak za analizu droga", Arhiv za higijenu rada i toksikologiju, vol.51, br. 4, str. 409-420, 2000. [Online]. Dostupno na: https://hrcak.srce.hr/747. [Citirano: 22.02.2019.]

Sažetak
Hair testing for drugs of abuse has the advantage of prolonged detection over blood, saliva, or urine analysis and is a useful diagnostic complement to them. This paper describes the main characteristics of hair as a biological sample and the mechanisms of incorporation, retention, and loss of drugs of abuse. The overview is confined to the most common procedures for determination of drugs of abuse, that is, those which involve gas chromatography – mass spectrometry (GC-MS). Each procedure basically includes the same steps: hair washing (decontamination), cutting, extraction/digestion, clean-up, and derivatisation. Although the analysis of hair has been worked out in detail, interpretation of findings of drugs of abuse in hair is complex. The content of hair is not uniform all along; a drug does not necessarily enter through the root; there are differences in hair growth; cosmetic treatment, purity of the taken drug, and the hair colour may affect the concentration of drugs of abuse in hair. The interpretation of findings must take all that into account. Positive findings of drugs of abuse in hair reflect chronic/recurring consumption but do not positively establish the quantity or time of consumption.

Ključne riječi
decontamination; GC/MS technique; passive exposure

Hrčak ID: 747

URI
https://hrcak.srce.hr/747

[hrvatski]

Posjeta: 7.186 *