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Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties

VENKADARI RAMMOHAN GUPTA
SRINIVAS MUTALIK
MADHOBHAI M. PATEL
GIRISH K. JANI

Puni tekst: engleski, pdf (188 KB) str. 173-184 preuzimanja: 2.447* citiraj
APA 6th Edition
GUPTA, V.R., MUTALIK, S., PATEL, M.M. i JANI, G.K. (2007). Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties. Acta Pharmaceutica, 57 (2), 173-184. Preuzeto s https://hrcak.srce.hr/9844
MLA 8th Edition
GUPTA, VENKADARI RAMMOHAN, et al. "Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties." Acta Pharmaceutica, vol. 57, br. 2, 2007, str. 173-184. https://hrcak.srce.hr/9844. Citirano 16.06.2019.
Chicago 17th Edition
GUPTA, VENKADARI RAMMOHAN, SRINIVAS MUTALIK, MADHOBHAI M. PATEL i GIRISH K. JANI. "Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties." Acta Pharmaceutica 57, br. 2 (2007): 173-184. https://hrcak.srce.hr/9844
Harvard
GUPTA, V.R., et al. (2007). 'Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties', Acta Pharmaceutica, 57(2), str. 173-184. Preuzeto s: https://hrcak.srce.hr/9844 (Datum pristupa: 16.06.2019.)
Vancouver
GUPTA VR, MUTALIK S, PATEL MM, JANI GK. Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties. Acta Pharm. [Internet]. 2007 [pristupljeno 16.06.2019.];57(2):173-184. Dostupno na: https://hrcak.srce.hr/9844
IEEE
V.R. GUPTA, S. MUTALIK, M.M. PATEL i G.K. JANI, "Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties", Acta Pharmaceutica, vol.57, br. 2, str. 173-184, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/9844. [Citirano: 16.06.2019.]

Sažetak
Celecoxib spherical agglomerates were prepared with polyvinylpyrrolidone (PVP) using acetone, water and chloroform as solvent, non-solvent and bridging liquid, respectively. The agglomerates were characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), IR spectroscopic studies and scanning electron microscopy (SEM). The IR spectroscopy and DSC results indicated the absence of any interactions between drug and additives. XRD studies showed a decrease in crystallinity in agglomerates. The crystals exhibited significantly improved micromeritic properties compared to pure drug. The loading efficiency (% or mg drug per 100 mg crystals) was in the range of 93.9 ± 2.3 and 97.3 ± 1.3% (n = 3), with all formulations. The aqueous solubility and dissolution rate of the drug from crystals was significantly (p < 0.05) increased (nearly two times). The solubility and in vitro drug release rates increased with an increase in PVP concentration (from 2.5 to 10%). The SEM studies showed that the crystal possesses a good spherical shape with smooth and regular surface.

Ključne riječi
celecoxib; spherical crystallization; solubility; dissolution rate; micromeritic properties

Hrčak ID: 9844

URI
https://hrcak.srce.hr/9844

[hrvatski]

Posjeta: 2.824 *