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Development and evaluation of carvedilol transdermal patches
YUVERAJ SINGH TANWAR
CHETAN SINGH CHAUHAN
Puni tekst: engleski, pdf (84 KB)
APA 6th Edition
TANWAR, Y.S., CHAUHAN, C.S. i SHARMA, A. (2007). Development and evaluation of carvedilol transdermal patches. Acta Pharmaceutica, 57 (2), 151-159. Preuzeto s https://hrcak.srce.hr/9851
MLA 8th Edition
TANWAR, YUVERAJ SINGH, et al. "Development and evaluation of carvedilol transdermal patches." Acta Pharmaceutica, vol. 57, br. 2, 2007, str. 151-159. https://hrcak.srce.hr/9851. Citirano 22.02.2019.
Chicago 17th Edition
TANWAR, YUVERAJ SINGH, CHETAN SINGH CHAUHAN i ANSHU SHARMA. "Development and evaluation of carvedilol transdermal patches." Acta Pharmaceutica 57, br. 2 (2007): 151-159. https://hrcak.srce.hr/9851
TANWAR, Y.S., CHAUHAN, C.S., i SHARMA, A. (2007). 'Development and evaluation of carvedilol transdermal patches', Acta Pharmaceutica, 57(2), str. 151-159. Preuzeto s: https://hrcak.srce.hr/9851 (Datum pristupa: 22.02.2019.)
TANWAR YS, CHAUHAN CS, SHARMA A. Development and evaluation of carvedilol transdermal patches. Acta Pharm. [Internet]. 2007 [pristupljeno 22.02.2019.];57(2):151-159. Dostupno na: https://hrcak.srce.hr/9851
Y.S. TANWAR, C.S. CHAUHAN i A. SHARMA, "Development and evaluation of carvedilol transdermal patches", Acta Pharmaceutica, vol.57, br. 2, str. 151-159, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/9851. [Citirano: 22.02.2019.]
Transdermal patches of carvedilol with a HPMC-drug reservoir were prepared by the solvent evaporation technique. In this investigation, the membranes of Eudragit RL100 and Eudragit RS100 were cast to achieve controlled release of the drug. The prepared patches possessed satisfactory physicochemical characteristics. Thickness, mass and drug content were uniform in prepared batches. Moisture vapour transmission through the patches followed zero-order kinetics. In vitro permeation studies were performed using a K-C diffusion cell across hairless guinea pig skin and followed super case II transport mechanism. The effects of non-ionic surfactants Tween 80 and Span 80 on drug permeation were studied. The non-ionic surfactants in the patches increased the permeation rate, Span 80 exhibiting better enhancement relative to Tween 80. The patches were seemingly free of potentially hazardous skin irritation.
carvedilol; transdermal patches; in vitro permeation; permeation rate
Hrčak ID: 9851
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