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Acta Pharmaceutica, Vol. 57 No. 2, 2007.

Kratko priopćenje

Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbon tetrachloride-induced hepatic injury in rats

TATJANA KADIFKOVA PANOVSKA
SVETLANA KULEVANOVA
ICKO GJORGOSKI
Mirjana BOGDANOVA
GORDANA PETRUSHEVSKA

Puni tekst: engleski, pdf (157 KB) str. 241-248 preuzimanja: 476* citiraj
APA 6th Edition
KADIFKOVA PANOVSKA, T., KULEVANOVA, S., GJORGOSKI, I., BOGDANOVA, M. i PETRUSHEVSKA, G. (2007). Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbon tetrachloride-induced hepatic injury in rats. Acta Pharmaceutica, 57 (2), 241-248. Preuzeto s https://hrcak.srce.hr/9853
MLA 8th Edition
KADIFKOVA PANOVSKA, TATJANA, et al. "Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbon tetrachloride-induced hepatic injury in rats." Acta Pharmaceutica, vol. 57, br. 2, 2007, str. 241-248. https://hrcak.srce.hr/9853. Citirano 23.02.2019.
Chicago 17th Edition
KADIFKOVA PANOVSKA, TATJANA, SVETLANA KULEVANOVA, ICKO GJORGOSKI, Mirjana BOGDANOVA i GORDANA PETRUSHEVSKA. "Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbon tetrachloride-induced hepatic injury in rats." Acta Pharmaceutica 57, br. 2 (2007): 241-248. https://hrcak.srce.hr/9853
Harvard
KADIFKOVA PANOVSKA, T., et al. (2007). 'Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbon tetrachloride-induced hepatic injury in rats', Acta Pharmaceutica, 57(2), str. 241-248. Preuzeto s: https://hrcak.srce.hr/9853 (Datum pristupa: 23.02.2019.)
Vancouver
KADIFKOVA PANOVSKA T, KULEVANOVA S, GJORGOSKI I, BOGDANOVA M, PETRUSHEVSKA G. Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbon tetrachloride-induced hepatic injury in rats. Acta Pharm. [Internet]. 2007 [pristupljeno 23.02.2019.];57(2):241-248. Dostupno na: https://hrcak.srce.hr/9853
IEEE
T. KADIFKOVA PANOVSKA, S. KULEVANOVA, I. GJORGOSKI, M. BOGDANOVA i G. PETRUSHEVSKA, "Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbon tetrachloride-induced hepatic injury in rats", Acta Pharmaceutica, vol.57, br. 2, str. 241-248, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/9853. [Citirano: 23.02.2019.]

Sažetak
Hepatoprotective activity of the ethyl acetate extract of Teucrium polium (L.) was investigated using rats with CCl4-induced liver damage. Specific biochemical parameters (glutathione peroxidase, superoxide dismutase, reduced glutathione and total antioxidative status) were estimated in blood and in liver homogenate. Lipid peroxidation in CCl4-intoxicated rats was evidenced by a marked increment in the levels of thiobarbituric acid reactive substances. Histopatological examinations of the liver were undertaken to monitor the liver status. Silymarin was used as a standard to compare the hepatoprotective activity of the extract. Some biochemical parameters in groups treated with the Teucrium polium extract at a dose of 25 mg kg-1, showed significantly different values than that of the CCl4-treated group. The liver biopsy of all experimental rat groups treated with the Teucrium polium ethyl acetate extract showed significant restoration of the normal histomorphological pattern of liver cells. The study substantiates the potential hepatoprotective activity of the ethyl acetate extract of Teucrium polium L.

Ključne riječi
Teucrium polium (Lamiaceae); hepatoprotective effect; carbon tetrachloride; sylimarin; glutathione

Hrčak ID: 9853

URI
https://hrcak.srce.hr/9853

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