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Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals

KANAKAPURA BASAVAIAH
CHANDRASHEKAR PRAMEELA HULLIKAL
CHIKKASWAMY SOMASHEKAR BANKAVADI

Puni tekst: engleski, pdf (75 KB) str. 221-230 preuzimanja: 846* citiraj
APA 6th Edition
BASAVAIAH, K., HULLIKAL, C.P. i BANKAVADI, C.S. (2007). Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals. Acta Pharmaceutica, 57 (2), 221-230. Preuzeto s https://hrcak.srce.hr/9854
MLA 8th Edition
BASAVAIAH, KANAKAPURA, et al. "Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals." Acta Pharmaceutica, vol. 57, br. 2, 2007, str. 221-230. https://hrcak.srce.hr/9854. Citirano 20.06.2019.
Chicago 17th Edition
BASAVAIAH, KANAKAPURA, CHANDRASHEKAR PRAMEELA HULLIKAL i CHIKKASWAMY SOMASHEKAR BANKAVADI. "Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals." Acta Pharmaceutica 57, br. 2 (2007): 221-230. https://hrcak.srce.hr/9854
Harvard
BASAVAIAH, K., HULLIKAL, C.P., i BANKAVADI, C.S. (2007). 'Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals', Acta Pharmaceutica, 57(2), str. 221-230. Preuzeto s: https://hrcak.srce.hr/9854 (Datum pristupa: 20.06.2019.)
Vancouver
BASAVAIAH K, HULLIKAL CP, BANKAVADI CS. Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals. Acta Pharm. [Internet]. 2007 [pristupljeno 20.06.2019.];57(2):221-230. Dostupno na: https://hrcak.srce.hr/9854
IEEE
K. BASAVAIAH, C.P. HULLIKAL i C.S. BANKAVADI, "Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals", Acta Pharmaceutica, vol.57, br. 2, str. 221-230, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/9854. [Citirano: 20.06.2019.]

Sažetak
A spectrophotometric method is described for assay of pefloxacin mesylate (PFM) in bulk drug and in tablets. The method is based on back extraction of the bromophenol blue dye at pH 5.2 from the dye-drug ion pair followed by measurement of the dye absorbance at 590 nm. The working conditions of the method were investigated and optimized. Beer’s law plot showed a good correlation in the concentration range of 0.15–1.25 g mL1. Sensitivity indices such as molar absorptivity, limits of detection and quantification are reported. Intra-day and inter-day precision, and accuracy of the methods were established according to the ICH guidelines, and the er values were in the range of –1.7 to 1.8% with RSD values ranging from 1.0 to 1.1%. The method was successfully applied to the assay of PFM in tablet preparations with recoveries varying from 97.5 to 101.9%, with standard deviation in the range of 0.6 to 1.9. The results were statistically compared with those of the reference method by applying Student's t-test and F-test. Accuracy evaluated by means of the spike recovery method ranged from 97.0 to 106.0%, with precision better than 3%.

Ključne riječi
pefloxacin mesylate; assay; spectrophotometry; bromophenol blue; pharmaceuticals

Hrčak ID: 9854

URI
https://hrcak.srce.hr/9854

[hrvatski]

Posjeta: 1.309 *