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Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals

KANAKAPURA BASAVAIAH
CHANDRASHEKAR PRAMEELA HULLIKAL
CHIKKASWAMY SOMASHEKAR BANKAVADI

Fulltext: english, pdf (75 KB) pages 221-230 downloads: 866* cite
APA 6th Edition
BASAVAIAH, K., HULLIKAL, C.P. & BANKAVADI, C.S. (2007). Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals. Acta Pharmaceutica, 57 (2), 221-230. Retrieved from https://hrcak.srce.hr/9854
MLA 8th Edition
BASAVAIAH, KANAKAPURA, et al. "Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals." Acta Pharmaceutica, vol. 57, no. 2, 2007, pp. 221-230. https://hrcak.srce.hr/9854. Accessed 20 Jul. 2019.
Chicago 17th Edition
BASAVAIAH, KANAKAPURA, CHANDRASHEKAR PRAMEELA HULLIKAL and CHIKKASWAMY SOMASHEKAR BANKAVADI. "Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals." Acta Pharmaceutica 57, no. 2 (2007): 221-230. https://hrcak.srce.hr/9854
Harvard
BASAVAIAH, K., HULLIKAL, C.P., and BANKAVADI, C.S. (2007). 'Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals', Acta Pharmaceutica, 57(2), pp. 221-230. Available at: https://hrcak.srce.hr/9854 (Accessed 20 July 2019)
Vancouver
BASAVAIAH K, HULLIKAL CP, BANKAVADI CS. Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals. Acta Pharm. [Internet]. 2007 [cited 2019 July 20];57(2):221-230. Available from: https://hrcak.srce.hr/9854
IEEE
K. BASAVAIAH, C.P. HULLIKAL and C.S. BANKAVADI, "Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals", Acta Pharmaceutica, vol.57, no. 2, pp. 221-230, 2007. [Online]. Available: https://hrcak.srce.hr/9854. [Accessed: 20 July 2019]

Abstracts
A spectrophotometric method is described for assay of pefloxacin mesylate (PFM) in bulk drug and in tablets. The method is based on back extraction of the bromophenol blue dye at pH 5.2 from the dye-drug ion pair followed by measurement of the dye absorbance at 590 nm. The working conditions of the method were investigated and optimized. Beer’s law plot showed a good correlation in the concentration range of 0.15–1.25 g mL1. Sensitivity indices such as molar absorptivity, limits of detection and quantification are reported. Intra-day and inter-day precision, and accuracy of the methods were established according to the ICH guidelines, and the er values were in the range of –1.7 to 1.8% with RSD values ranging from 1.0 to 1.1%. The method was successfully applied to the assay of PFM in tablet preparations with recoveries varying from 97.5 to 101.9%, with standard deviation in the range of 0.6 to 1.9. The results were statistically compared with those of the reference method by applying Student's t-test and F-test. Accuracy evaluated by means of the spike recovery method ranged from 97.0 to 106.0%, with precision better than 3%.

Keywords
pefloxacin mesylate; assay; spectrophotometry; bromophenol blue; pharmaceuticals

Hrčak ID: 9854

URI
https://hrcak.srce.hr/9854

[croatian]

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