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Pregledni rad
https://doi.org/10.11613/BM.2013.021

Copeptin and its potential role in diagnosis and prognosis of various diseases

Lidija Dobša   ORCID icon orcid.org/0000-0002-3230-5322 ; Health Institution Varaždin County, Medical Biochemistry Laboratory, Varaždin, Croatia
Kido Cullen Edozien ; Mater Dei Hospital, Msida, Malta

Puni tekst: engleski, pdf (239 KB) str. 172-190 preuzimanja: 535* citiraj
APA 6th Edition
Dobša, L. i Cullen Edozien, K. (2013). Copeptin and its potential role in diagnosis and prognosis of various diseases. Biochemia Medica, 23 (2), 172-190. https://doi.org/10.11613/BM.2013.021
MLA 8th Edition
Dobša, Lidija i Kido Cullen Edozien. "Copeptin and its potential role in diagnosis and prognosis of various diseases." Biochemia Medica, vol. 23, br. 2, 2013, str. 172-190. https://doi.org/10.11613/BM.2013.021. Citirano 27.01.2021.
Chicago 17th Edition
Dobša, Lidija i Kido Cullen Edozien. "Copeptin and its potential role in diagnosis and prognosis of various diseases." Biochemia Medica 23, br. 2 (2013): 172-190. https://doi.org/10.11613/BM.2013.021
Harvard
Dobša, L., i Cullen Edozien, K. (2013). 'Copeptin and its potential role in diagnosis and prognosis of various diseases', Biochemia Medica, 23(2), str. 172-190. https://doi.org/10.11613/BM.2013.021
Vancouver
Dobša L, Cullen Edozien K. Copeptin and its potential role in diagnosis and prognosis of various diseases. Biochemia Medica [Internet]. 2013 [pristupljeno 27.01.2021.];23(2):172-190. https://doi.org/10.11613/BM.2013.021
IEEE
L. Dobša i K. Cullen Edozien, "Copeptin and its potential role in diagnosis and prognosis of various diseases", Biochemia Medica, vol.23, br. 2, str. 172-190, 2013. [Online]. https://doi.org/10.11613/BM.2013.021

Sažetak
The need for faster diagnosis, more accurate prognostic assessment and treatment decisions in vari-ous diseases has lead to the investigations of new biomarkers. The hope is that this new biomarkers will enable early decision making in clinical practice. Arginine vasopressin (AVP) is one of the main hormones of the hypothalamic-pituitary-adrenal axis. Its main stimulus for secretion is hyperosmolarity, but AVP system is also stimulated by exposure of the body to endogenous stress. Reliable measurement of AVP concentration is difficult because it is subject to preanalytical and analytical errors. It is therefore not used in clinical practice. Copeptin, a 39-aminoacid glycopeptide, is a C-terminal part of the precursor pre-provasopressin (pre-proAVP). Activation of AVP system stimu-lates copeptin secretion into the circulation from the posterior pituitary gland in equimolar amounts with AVP. Therefore, copeptin directly reflects AVP concentration and can be used as surrogate bio-marker of AVP secretion. Even mild to moderate stress situations contribute to release of copeptin. These reasons have lead to a handful of research on copeptin in various diseases. This review sum-marizes the current achievements in the research of copeptin as a diagnostic and prognostic marker and also discusses its association in different disease processes.

Ključne riječi
human copeptin; endogenous stress; diagnostic accuracy; prognosis

Hrčak ID: 103793

URI
https://hrcak.srce.hr/103793

Posjeta: 874 *