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EPIDEMIOLOGY OF INVASIVE BREAST CANCER ACCORDING TO HISTOPATHOLOGIC AND IMMUNOHISTOCHEMISTRY PROGNOSTIC FACTORS

ZVONIMIR ZORE ; Sestre milosrdnice University Hospital Center, Department of Oncologic Surgery, Zagreb, Croatia
MLADEN STANEC ; Sestre milosrdnice University Hospital Center, Department of Oncologic Surgery, Zagreb, Croatia
IVAN MILAS ; Sestre milosrdnice University Hospital Center, Department of Oncologic Surgery, Zagreb, Croatia
IVAN PENAVIĆ ; Sestre milosrdnice University Hospital Center, Department of Oncologic Surgery, Zagreb, Croatia
TOMISLAV OREŠIĆ ; Sestre milosrdnice University Hospital Center, Department of Oncologic Surgery, Zagreb, Croatia
ANDREJ ROTH ; Sestre milosrdnice University Hospital Center, Department of Oncologic Surgery, Zagreb, Croatia
DUBRAVKA MUŽINA ; Sestre milosrdnice University Hospital Center, Department of Oncologic Surgery, Zagreb, Croatia

Puni tekst: hrvatski, pdf (290 KB) str. 315-320 preuzimanja: 2.541* citiraj
APA 6th Edition
ZORE, Z., STANEC, M., MILAS, I., PENAVIĆ, I., OREŠIĆ, T., ROTH, A. i MUŽINA, D. (2012). EPIDEMIOLOGIJA INVAZIVNIH TUMORA DOJKE S OBZIROM NA PATOHISTOLOŠKE I IMUNOHISTOKEMIJSKE PROGNOSTIČKE ČIMBENIKE. Acta medica Croatica, 66 (4), 315-320. Preuzeto s https://hrcak.srce.hr/104101
MLA 8th Edition
ZORE, ZVONIMIR, et al. "EPIDEMIOLOGIJA INVAZIVNIH TUMORA DOJKE S OBZIROM NA PATOHISTOLOŠKE I IMUNOHISTOKEMIJSKE PROGNOSTIČKE ČIMBENIKE." Acta medica Croatica, vol. 66, br. 4, 2012, str. 315-320. https://hrcak.srce.hr/104101. Citirano 09.12.2019.
Chicago 17th Edition
ZORE, ZVONIMIR, MLADEN STANEC, IVAN MILAS, IVAN PENAVIĆ, TOMISLAV OREŠIĆ, ANDREJ ROTH i DUBRAVKA MUŽINA. "EPIDEMIOLOGIJA INVAZIVNIH TUMORA DOJKE S OBZIROM NA PATOHISTOLOŠKE I IMUNOHISTOKEMIJSKE PROGNOSTIČKE ČIMBENIKE." Acta medica Croatica 66, br. 4 (2012): 315-320. https://hrcak.srce.hr/104101
Harvard
ZORE, Z., et al. (2012). 'EPIDEMIOLOGIJA INVAZIVNIH TUMORA DOJKE S OBZIROM NA PATOHISTOLOŠKE I IMUNOHISTOKEMIJSKE PROGNOSTIČKE ČIMBENIKE', Acta medica Croatica, 66(4), str. 315-320. Preuzeto s: https://hrcak.srce.hr/104101 (Datum pristupa: 09.12.2019.)
Vancouver
ZORE Z, STANEC M, MILAS I, PENAVIĆ I, OREŠIĆ T, ROTH A i sur. EPIDEMIOLOGIJA INVAZIVNIH TUMORA DOJKE S OBZIROM NA PATOHISTOLOŠKE I IMUNOHISTOKEMIJSKE PROGNOSTIČKE ČIMBENIKE. Acta medica Croatica [Internet]. 2012 [pristupljeno 09.12.2019.];66(4):315-320. Dostupno na: https://hrcak.srce.hr/104101
IEEE
Z. ZORE, et al., "EPIDEMIOLOGIJA INVAZIVNIH TUMORA DOJKE S OBZIROM NA PATOHISTOLOŠKE I IMUNOHISTOKEMIJSKE PROGNOSTIČKE ČIMBENIKE", Acta medica Croatica, vol.66, br. 4, str. 315-320, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/104101. [Citirano: 09.12.2019.]

Sažetak
The aim of this study was to analyze the TNM classification factors of invasive breast cancer that can be affected by the national program for early detection of breast cancer in the Republic of Croatia. The other analyzed factors related to histology and immunohistochemistry have no such impact as they are related to biological behavior and aggressiveness of malignant breast tumors, thus providing useful predictive and prognostic information. The study was performed at Department of Oncologic Surgery, Sestre milosrdnice University Hospital Center, and included 75 patients surgically treated for invasive breast cancer during the period of one month in 2011, mean age 64±11.36 (range 36-86) years. Most of the patients (68%) with malignant breast disease were diagnosed in a localized stage, which is consistent with the reports from developed European countries. The size of the newly discovered tumors showed continuation of a trend of detecting tumors of ever less size and a lower percentage of pT3 pT4 tumors. This result proved superior to those reported from many European countries. The results of correlation analysis, tumor size, estrogen and progesterone receptor, HER-2 protein, Ki-67, and histologic tumor grade, tumor size did not show significant correlation with any of these parameters. Concordant expression of phenotype (ER+, PR+) receptor pairs and negative HER-2 was recorded in most study patients. The second most frequent group had tumors with so-called ‘triple-negative’ immunohistochemistry negative phenotype (ER-, PR-, HER-2). In conclusion, the program of early detection of breast cancer in the Republic of Croatia and at the University Hospital for Tumors justifies its existence for revealing malignant breast tumors at an earlier stage of the disease considering the size local stage of newly diagnosed tumors.

Ključne riječi
epidemiology; histopathology; immunohistochemistry; invasive breast tumors

Hrčak ID: 104101

URI
https://hrcak.srce.hr/104101

[hrvatski]

Posjeta: 3.205 *