hrcak mascot   Srce   HID

Izvorni znanstveni članak

PATHWAYS LINKING EARLY LIFE STRESS, METABOLIC SYNDROME, AND THE INFLAMMATORY MARKER FIBRINOGEN IN DEPRESSED INPATIENTS

Sara Zeugmann ; Department of Psychiatry and Psychotherapy, Charité, Campus Benjamin Franklin, Berlin, Germany
Arnim Quante ; Department of Psychiatry and Psychotherapy, Charité, Campus Benjamin Franklin, Berlin, Germany
Louchka Popova-Zeugmann ; Department of Computer Science, Humboldt University, Berlin, Germany
Wolfgang Kössler ; Department of Computer Science, Humboldt University, Berlin, Germany
Isabella Heuser ; Department of Psychiatry and Psychotherapy, Charité, Campus Benjamin Franklin, Berlin, Germany
Ion Anghelescu ; Department of Psychiatry and Psychotherapy, Charité, Campus Benjamin Franklin, Berlin, Germany

Puni tekst: engleski, pdf (275 KB) str. 57-65 preuzimanja: 590* citiraj
APA 6th Edition
Zeugmann, S., Quante, A., Popova-Zeugmann, L., Kössler, W., Heuser, I. i Anghelescu, I. (2012). PATHWAYS LINKING EARLY LIFE STRESS, METABOLIC SYNDROME, AND THE INFLAMMATORY MARKER FIBRINOGEN IN DEPRESSED INPATIENTS. Psychiatria Danubina, 24. (1.), 57-65. Preuzeto s https://hrcak.srce.hr/106204
MLA 8th Edition
Zeugmann, Sara, et al. "PATHWAYS LINKING EARLY LIFE STRESS, METABOLIC SYNDROME, AND THE INFLAMMATORY MARKER FIBRINOGEN IN DEPRESSED INPATIENTS." Psychiatria Danubina, vol. 24., br. 1., 2012, str. 57-65. https://hrcak.srce.hr/106204. Citirano 05.04.2020.
Chicago 17th Edition
Zeugmann, Sara, Arnim Quante, Louchka Popova-Zeugmann, Wolfgang Kössler, Isabella Heuser i Ion Anghelescu. "PATHWAYS LINKING EARLY LIFE STRESS, METABOLIC SYNDROME, AND THE INFLAMMATORY MARKER FIBRINOGEN IN DEPRESSED INPATIENTS." Psychiatria Danubina 24., br. 1. (2012): 57-65. https://hrcak.srce.hr/106204
Harvard
Zeugmann, S., et al. (2012). 'PATHWAYS LINKING EARLY LIFE STRESS, METABOLIC SYNDROME, AND THE INFLAMMATORY MARKER FIBRINOGEN IN DEPRESSED INPATIENTS', Psychiatria Danubina, 24.(1.), str. 57-65. Preuzeto s: https://hrcak.srce.hr/106204 (Datum pristupa: 05.04.2020.)
Vancouver
Zeugmann S, Quante A, Popova-Zeugmann L, Kössler W, Heuser I, Anghelescu I. PATHWAYS LINKING EARLY LIFE STRESS, METABOLIC SYNDROME, AND THE INFLAMMATORY MARKER FIBRINOGEN IN DEPRESSED INPATIENTS. Psychiatria Danubina [Internet]. 2012 [pristupljeno 05.04.2020.];24.(1.):57-65. Dostupno na: https://hrcak.srce.hr/106204
IEEE
S. Zeugmann, A. Quante, L. Popova-Zeugmann, W. Kössler, I. Heuser i I. Anghelescu, "PATHWAYS LINKING EARLY LIFE STRESS, METABOLIC SYNDROME, AND THE INFLAMMATORY MARKER FIBRINOGEN IN DEPRESSED INPATIENTS", Psychiatria Danubina, vol.24., br. 1., str. 57-65, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/106204. [Citirano: 05.04.2020.]

Sažetak
Background: Previous research has shown that metabolic syndrome as well as early life stress can account for
immunoactivation (e.g. in the form of altered fibrinogen levels) in patients with major depression. This study aims at assessing the
relationship between components of metabolic syndrome, early life stress and fibrinogen levels, taking the severity of depression into
consideration.
Subjects and methods: Measures of early life stress and signs of metabolic syndrome were collected in 58 adult inpatients
diagnosed with depression. The relationships between the factors were assessed by means of path analyses. Two main models were
tested: the first model with metabolic syndrome mediating between early life stress and fibrinogen levels and the second model
without the mediating effect of metabolic syndrome.
Results: The first model was not supported by our data (χ²=7.02, df=1, p=0.008, CFI=0.00, NNFI=-9.44, RMSEA=0.50). The
second model however provided an excellent fit for the data (χ²=0.02, df=1, p=0.90, CFI=1.00, NNFI=2.71, RMSEA=0.00).
Extending the models by introducing severity of depression into them did not yield good indices of fit.
Conclusions: The developmental trajectory between early life stress and inflammation appears not to be mediated by metabolic
syndrome associated factors in our sample. Possible reasons including severity and type of early life stress, as well as potential
epigenetic influences are discussed.

Ključne riječi
early life stress; metabolic syndrome; inflammatory; fibrinogen; depression

Hrčak ID: 106204

URI
https://hrcak.srce.hr/106204

Posjeta: 738 *