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Vitiligo: Is It Grace or Curse?
Ola Ahmed Bakry
; Menoufiya University
Vitiligo is a common depigmented skin disorder that is caused by selective destruction of melanocytes. Since melanin is a unique light absorbing and ultraviolet filtering pigment, it is generally accepted that its main function resides in the protection of skin cells against the deleterious effect of ultraviolet rays (UVR). Occurrence of skin cancer in long lasting vitiligo is rare despite multiple evidences of DNA damage. The aim of the study was to detect the expression of P53 and Mdm2 proteins in both depigmented as well as normally pigmented skin of vitiligo patients and to compare it to control subjects suffering from non melanoma skin cancer (NMSC).
Thirty-four patients with vitiligo and 30 age and sex matched patients with nodulo-ulcerative basal cell carcinoma (BCC) as a control group were selected. Both patients and control subjects have outdoor occupations. Skin biopsies were taken from each case (from depigmented and normaly pigmented UVR-exposed skin). Skin biopsies were taken from control subjects as well (from perilesional healthy skin). Histopathological examination of hematoxylin and eosin stained sections was done. Expression of P53 and Mdm2 proteins were examined immunohistochemically.
Both P53 and Mdm2 were strongly expressed in depigmented as well as normally pigmented skin of vitiligo patients. This expression involves the epidermis, skin adnexa and blood vessels with significant differences between cases and controls. These results suggest that the over-expression of P53 and Mdm2 proteins in both depigmented and normally pigmented skin of patients with vitiligo could contribute to the decreased occurrence of actinic damage and NMSC in these patients.
Hrčak ID: 106667
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