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Pregledni rad
https://doi.org/10.11613/BM.2013.032

Polymorphisms of genes involved in polycyclic aromatic hydrocarbons’biotransformation and atherosclerosis

Natalija Marinković ; Quintiles Zagreb LTD, Zagreb, Croatia
Daria Pašalić   ORCID icon orcid.org/0000-0002-5741-6168 ; Department of Medical Chemistry, Biochemistry and Clinical Chemistry, University of Zagreb, School of Medicine, Zagreb, Croatia
Slavica Potočki ; Department of Medical Chemistry, Biochemistry and Clinical Chemistry, University of Zagreb, School of Medicine, Zagreb, Croatia

Puni tekst: engleski, pdf (184 KB) str. 255-265 preuzimanja: 404* citiraj
APA 6th Edition
Marinković, N., Pašalić, D. i Potočki, S. (2013). Polymorphisms of genes involved in polycyclic aromatic hydrocarbons’biotransformation and atherosclerosis. Biochemia Medica, 23 (3), 255-265. https://doi.org/10.11613/BM.2013.032
MLA 8th Edition
Marinković, Natalija, et al. "Polymorphisms of genes involved in polycyclic aromatic hydrocarbons’biotransformation and atherosclerosis." Biochemia Medica, vol. 23, br. 3, 2013, str. 255-265. https://doi.org/10.11613/BM.2013.032. Citirano 20.01.2021.
Chicago 17th Edition
Marinković, Natalija, Daria Pašalić i Slavica Potočki. "Polymorphisms of genes involved in polycyclic aromatic hydrocarbons’biotransformation and atherosclerosis." Biochemia Medica 23, br. 3 (2013): 255-265. https://doi.org/10.11613/BM.2013.032
Harvard
Marinković, N., Pašalić, D., i Potočki, S. (2013). 'Polymorphisms of genes involved in polycyclic aromatic hydrocarbons’biotransformation and atherosclerosis', Biochemia Medica, 23(3), str. 255-265. https://doi.org/10.11613/BM.2013.032
Vancouver
Marinković N, Pašalić D, Potočki S. Polymorphisms of genes involved in polycyclic aromatic hydrocarbons’biotransformation and atherosclerosis. Biochemia Medica [Internet]. 2013 [pristupljeno 20.01.2021.];23(3):255-265. https://doi.org/10.11613/BM.2013.032
IEEE
N. Marinković, D. Pašalić i S. Potočki, "Polymorphisms of genes involved in polycyclic aromatic hydrocarbons’biotransformation and atherosclerosis", Biochemia Medica, vol.23, br. 3, str. 255-265, 2013. [Online]. https://doi.org/10.11613/BM.2013.032

Sažetak
Polycyclic aromatic hydrocarbons (PAHs) are among the most prevalent environmental pollutants and result from the incomplete combustion of hydrocarbons (coal and gasoline, fossil fuel combustion, byproducts of industrial processing, natural emission, cigarette smoking, etc.). The first phase of xenobiotic biotransformation in the PAH metabolism includes activities of cytochrome P450 from the CYP1 family and microsomal epoxide hydrolase. The products of this biotransformation are reactive oxygen species that are transformed in the second phase through the formation of conjugates with glutathione, glucuronate or sulphates. PAH exposure may lead to PAH-DNA adduct formation or induce an inflammatory atherosclerotic plaque phenotype. Several genetic polymorphisms of genes encoded for enzymes involved in PAH biotransformation have been proven to lead to the development of diseases. Enzyme CYP P450 1A1, which is encoded by the CYP1A1 gene, is vital in the monooxygenation of lipofilic substrates, while GSTM1 and GSTT1 are the most abundant isophorms that conjugate and neutralize oxygen products. Some single nucleotide polymorphisms of the CYP1A1 gene as well as the deletion polymorphisms of GSTT1 and GSTM1 may alter the final specific cellular inflammatory respond. Occupational exposure or conditions from the living environment can contribute to the production of PAH metabolites with adverse effects on human health. The aim of this study was to obtain data on biotransformation and atherosclerosis, as well as data on the gene polymorphisms involved in biotransformation, in order to better study gene expression and further elucidate the interaction between genes and the environment.

Ključne riječi
atherosclerosis; biotransformations; genetic polymorphism; polycyclic aromatic hydrocarbons

Hrčak ID: 109232

URI
https://hrcak.srce.hr/109232

Posjeta: 716 *