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https://doi.org/10.5562/cca2240

Synthesis and Anti-inflammatory Activity of Novel Furochromenes

Ivaylo Jivkov Elenkov ; Fidelta Ltd., Prilaz baruna Filipovića 29, HR-10000 Zagreb, Croatia
Boška Hrvačić ; Fidelta Ltd., Prilaz baruna Filipovića 29, HR-10000 Zagreb, Croatia
Stribor Marković ; Institute of Immunology, Inc., Rockefellerova 2, HR-10000 Zagreb, Croatia
Milan Mesić ; Fidelta Ltd., Prilaz baruna Filipovića 29, HR-10000 Zagreb, Croatia
Andreja Čempuh Klonkay ; PLIVA Croatia Ltd, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia
Lidija Lerman ; PLIVA Croatia Ltd, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia
Anita Filipović Sučić ; Croatian Agency for Medicinal Products and Medical Devices, Ksaverska cesta 4, HR-10000 Zagreb, Croatia
Ines Vujasinović ; Fidelta Ltd., Prilaz baruna Filipovića 29, HR-10000 Zagreb, Croatia
Berislav Bošnjak ; Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Experimental Allergy, Medical University of Vienna, Lazarettgasse 19, A-1090 Vienna, Austria
Karmen Brajša ; Fidelta Ltd., Prilaz baruna Filipovića 29, HR-10000 Zagreb, Croatia
Dinko Žiher ; Fidelta Ltd., Prilaz baruna Filipovića 29, HR-10000 Zagreb, Croatia
Nada Košutić Hulita ; PLIVA Croatia Ltd, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia
Ivica Malnar   ORCID icon orcid.org/0000-0002-3226-4583 ; Croatian Agency for Medicinal Products and Medical Devices, Ksaverska cesta 4, HR-10000 Zagreb, Croatia

Puni tekst: engleski, pdf (2 MB) str. 253-264 preuzimanja: 939* citiraj
APA 6th Edition
Elenkov, I.J., Hrvačić, B., Marković, S., Mesić, M., Čempuh Klonkay, A., Lerman, L., ... Malnar, I. (2013). Synthesis and Anti-inflammatory Activity of Novel Furochromenes. Croatica Chemica Acta, 86 (3), 253-264. https://doi.org/10.5562/cca2240
MLA 8th Edition
Elenkov, Ivaylo Jivkov, et al. "Synthesis and Anti-inflammatory Activity of Novel Furochromenes." Croatica Chemica Acta, vol. 86, br. 3, 2013, str. 253-264. https://doi.org/10.5562/cca2240. Citirano 15.12.2019.
Chicago 17th Edition
Elenkov, Ivaylo Jivkov, Boška Hrvačić, Stribor Marković, Milan Mesić, Andreja Čempuh Klonkay, Lidija Lerman, Anita Filipović Sučić, et al. "Synthesis and Anti-inflammatory Activity of Novel Furochromenes." Croatica Chemica Acta 86, br. 3 (2013): 253-264. https://doi.org/10.5562/cca2240
Harvard
Elenkov, I.J., et al. (2013). 'Synthesis and Anti-inflammatory Activity of Novel Furochromenes', Croatica Chemica Acta, 86(3), str. 253-264. https://doi.org/10.5562/cca2240
Vancouver
Elenkov IJ, Hrvačić B, Marković S, Mesić M, Čempuh Klonkay A, Lerman L i sur. Synthesis and Anti-inflammatory Activity of Novel Furochromenes. Croatica Chemica Acta [Internet]. 2013 [pristupljeno 15.12.2019.];86(3):253-264. https://doi.org/10.5562/cca2240
IEEE
I.J. Elenkov, et al., "Synthesis and Anti-inflammatory Activity of Novel Furochromenes", Croatica Chemica Acta, vol.86, br. 3, str. 253-264, 2013. [Online]. https://doi.org/10.5562/cca2240

Sažetak
A series of variously substituted furochromenes, hemiacetals 2, acetals 3, and rearranged compounds 4, were synthesized from variously substituted 4-hydroxycoumarins and evaluated in several in vitro assays, inhibition of mast cell degranulation induced by the activation of Fcε receptor type I or calci-um ionophore and leukotriene B4 (LTB4) inhibition. The most active derivatives, 3p and 4p (8-iso-propyl substitution in coumarin ring) and 3r (5-methyl-8-chloro substitution), showed significant inhibition of mast cell degranulation (Fctriggered) and LTB4, and exhibited significant local anti-inflammatory activity in PMA induced ear edema in CD1 mice, with potency equal (compounds 3p and 4p) or better (compound 3r) in comparison with zileuton, a reference drug used. It might be a promising direction for developing novel drugs as potential agents for the treatment of allergies and other inflammatory diseases.(doi: 10.5562/cca2240)

Ključne riječi
furochromenes; 4-hydroxycoumarins; mast cell degranulation; leukotriene B4; anti-inflammatory activity; ear edema

Hrčak ID: 111298

URI
https://hrcak.srce.hr/111298

Posjeta: 1.310 *