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Pregledni rad
https://doi.org/10.2478/10004-1254-64-2013-2371

Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs

Katarina Mišković ; J. J. Strossmayer University, Faculty of Medicine, Department of Medicinal Chemistry, Biochemistry and Clinical Chemistry, Osijek, Croatia
Maro Bujak ; Ruđer Bošković Institute, Department of Molecular Medicine, Laboratory for Systems Biomedicine, Zagreb, Croatia
Mirela Baus Lončar ; Biomedicine, Zagreb, Croatia
Ljubica Glavaš-Obrovac ; J. J. Strossmayer University, Faculty of Medicine, Department of Medicinal Chemistry, Biochemistry and Clinical Chemistry, Osijek, Croatia

Puni tekst: engleski, pdf (170 KB) str. 593-601 preuzimanja: 2.370* citiraj
APA 6th Edition
Mišković, K., Bujak, M., Baus Lončar, M. i Glavaš-Obrovac, Lj. (2013). Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs. Arhiv za higijenu rada i toksikologiju, 64 (4), 593-601. https://doi.org/10.2478/10004-1254-64-2013-2371
MLA 8th Edition
Mišković, Katarina, et al. "Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs." Arhiv za higijenu rada i toksikologiju, vol. 64, br. 4, 2013, str. 593-601. https://doi.org/10.2478/10004-1254-64-2013-2371. Citirano 19.11.2019.
Chicago 17th Edition
Mišković, Katarina, Maro Bujak, Mirela Baus Lončar i Ljubica Glavaš-Obrovac. "Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs." Arhiv za higijenu rada i toksikologiju 64, br. 4 (2013): 593-601. https://doi.org/10.2478/10004-1254-64-2013-2371
Harvard
Mišković, K., et al. (2013). 'Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs', Arhiv za higijenu rada i toksikologiju, 64(4), str. 593-601. https://doi.org/10.2478/10004-1254-64-2013-2371
Vancouver
Mišković K, Bujak M, Baus Lončar M, Glavaš-Obrovac Lj. Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs. Arh Hig Rada Toksikol. [Internet]. 2013 [pristupljeno 19.11.2019.];64(4):593-601. https://doi.org/10.2478/10004-1254-64-2013-2371
IEEE
K. Mišković, M. Bujak, M. Baus Lončar i Lj. Glavaš-Obrovac, "Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs", Arhiv za higijenu rada i toksikologiju, vol.64, br. 4, str. 593-601, 2013. [Online]. https://doi.org/10.2478/10004-1254-64-2013-2371

Sažetak
DNA intercalating and minor groove binding compounds are new weapons in the battle against malignant diseases. These antineoplastic agents target the DNA molecule and interfere with the cell cycle leading to rapidly proliferating cell death. They are mainly derivates of a naturally occurring organic compound derived from a microorganism or plant. Intercalators usually act as topoisomerase I and/or II poisons, while the mechanisms of DNA minor groove binders are a combination of several steps including topoisomerase poisoning. This paper gives an overview of some of the developed DNA intercalating and minor groove binding compounds, as well as an explanation of their chemical structures, origins, and application in chemotherapy.

Ključne riječi
chemotherapy; DNA intercalator; DNA minor groove binder; organic compounds derivatives

Hrčak ID: 111788

URI
https://hrcak.srce.hr/111788

[hrvatski]

Posjeta: 2.679 *