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ASSESSMENT OF LIVER DISEASE SEVERITY IN PATIENTS WITH CHRONIC VIRAL HEPATITIS

IVICA GRGUREVIĆ   ORCID icon orcid.org/0000-0003-0520-3483 ; School of Medicine, University of Zagreb, Dubrava University Hospital, Clinical Department of Medicine, Department of Gastroenterology, Zagreb, Croatia
IRENA HRSTIĆ ; Pula General Hospital, Clinical Department of Internal Medicine, Department of Gastroenterology, Pula, Croatia
BORIS VUCELIĆ ; School of Medicine, University of Zagreb, Zagreb University Hospital Center, Clinical Department of Internal Medicine, Department of Gastroenterology, Zagreb, Croatia

Fulltext: croatian, pdf (420 KB) pages 291-301 downloads: 6.317* cite
APA 6th Edition
GRGUREVIĆ, I., HRSTIĆ, I. & VUCELIĆ, B. (2013). PROCJENA TEŽINE OŠTEĆENJA JETRE U BOLESNIKA S KRONIČNIM VIRUSNIM HEPATITISOM. Acta medica Croatica, 67 (4), 291-301. Retrieved from https://hrcak.srce.hr/113715
MLA 8th Edition
GRGUREVIĆ, IVICA, et al. "PROCJENA TEŽINE OŠTEĆENJA JETRE U BOLESNIKA S KRONIČNIM VIRUSNIM HEPATITISOM." Acta medica Croatica, vol. 67, no. 4, 2013, pp. 291-301. https://hrcak.srce.hr/113715. Accessed 20 Jan. 2021.
Chicago 17th Edition
GRGUREVIĆ, IVICA, IRENA HRSTIĆ and BORIS VUCELIĆ. "PROCJENA TEŽINE OŠTEĆENJA JETRE U BOLESNIKA S KRONIČNIM VIRUSNIM HEPATITISOM." Acta medica Croatica 67, no. 4 (2013): 291-301. https://hrcak.srce.hr/113715
Harvard
GRGUREVIĆ, I., HRSTIĆ, I., and VUCELIĆ, B. (2013). 'PROCJENA TEŽINE OŠTEĆENJA JETRE U BOLESNIKA S KRONIČNIM VIRUSNIM HEPATITISOM', Acta medica Croatica, 67(4), pp. 291-301. Available at: https://hrcak.srce.hr/113715 (Accessed 20 January 2021)
Vancouver
GRGUREVIĆ I, HRSTIĆ I, VUCELIĆ B. PROCJENA TEŽINE OŠTEĆENJA JETRE U BOLESNIKA S KRONIČNIM VIRUSNIM HEPATITISOM. Acta medica Croatica [Internet]. 2013 [cited 2021 January 20];67(4):291-301. Available from: https://hrcak.srce.hr/113715
IEEE
I. GRGUREVIĆ, I. HRSTIĆ and B. VUCELIĆ, "PROCJENA TEŽINE OŠTEĆENJA JETRE U BOLESNIKA S KRONIČNIM VIRUSNIM HEPATITISOM", Acta medica Croatica, vol.67, no. 4, pp. 291-301, 2013. [Online]. Available: https://hrcak.srce.hr/113715. [Accessed: 20 January 2021]

Abstracts
The best indicator of the severity of liver damage and prognosis in chronic viral hepatitis is extension of liver fibrosis. Extension of liver fibrosis can be assessed by liver biopsy and non-invasive physical or biological methods. Biopsy is used to define ethiology, severity (stage of fibrosis) and prognosis of liver disease. These informations are also usefull when estimating the risk-benefit and deciding on the modalities of antiviral therapy. Serological tests and elastography may distinguish significant fibrosis (F ≥2) from baseline fibrosis (AUROC 0.77-0.83 for serology and 0.84 for elastography) and cirrhosis from noncirrhotic stages (AUROC 0.77-0.86 for serology and 0.9-0.94 for elastography). Individual method of choice with best performance to distinguish cirrhosis from noncirrhotic stages of liver is elastography. Combination of serological tests and transient elastography has 93-95% accuracy to predict liver cirrhosis, and in case of concordant values of both tests biopsy could be avoided in 77-80% of patients. In case of discordant values or those in favour of intermediate stages of fibrosis liver biopsy should be performed because in these situations non-invasive tests are less reliable. According to several studies liver stiffness as assessed by transient elastography has high predictive value for the development of decom-pensated cirrhosis and portal hypertensive complications and may also discriminate the patients with respect to the predicted 5-year survival.

Keywords
chronic viral hepatitis; fibrosis; liver biopsy; elastography

Hrčak ID: 113715

URI
https://hrcak.srce.hr/113715

[croatian]

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