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Collegium antropologicum, Vol.37 No.3 Rujan 2013.

Izvorni znanstveni članak

Association between Red Blood Cell Count and Renal Function Exist in Type 1 Diabetic Patients in the Absence of Nephropathy

Tomislav Bulum ; University of Zagreb, School of Medicine, University Hospital »Merkur«, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and Metabolic Diseases, Zagreb, Croatia
Ingrid Prkačin ; University of Zagreb, School of Medicine, University Hospital »Merkur«, Department of Internal Medicine, Zagreb, Croatia
Kristina Blaslov ; University of Zagreb, School of Medicine, University Hospital »Merkur«, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and Metabolic Diseases, Zagreb, Croatia
Karin Zibar ; University of Zagreb, School of Medicine, University Hospital »Merkur«, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and Metabolic Diseases, Zagreb, Croati
Lea Duvnjak ; University of Zagreb, School of Medicine, University Hospital »Merkur«, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and Metabolic Diseases, Zagreb, Croatia

Puni tekst: engleski, pdf (99 KB) str. 777-782 preuzimanja: 140* citiraj
APA
Bulum, T., Prkačin, I., Blaslov, K., Zibar, K., Duvnjak, L. (2013). Association between Red Blood Cell Count and Renal Function Exist in Type 1 Diabetic Patients in the Absence of Nephropathy. Collegium antropologicum, 37(3), 777-782. Preuzeto s https://hrcak.srce.hr/118217

Sažetak
Anemia is a prevalent finding in patients with type 1 diabetes, particularly in those with albuminuria or reduced re- nal function. We investigated the relationship between red blood cell count (RBC) and renal function in type 1 diabetic patients with normal or mildly impaired renal function and urinary albumin excretion rate (UAE) <30 mg/24 h. Study included 313 type 1 diabetic patients with estimated glomerular filtration rate (eGFR) > 60 mL min –1 1.73 m –2 , and be- fore any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. UAE was measured from at least two 24-h urine samples. Hemoglobin (Hb), hematocrit (Hct), erythrocytes (E), serum iron and ferritin levels were signifi- cantly lower in subjects in the highest quartile of serum creatinine compared to those in lowest quartile (132 vs 148 g/L, 0.39 vs 0.42 L/L, 4.5 vs 4.8x10 12 /L, 13 vs 18 µmol/L, and 25 vs 103 µg/L, respectively, for all p<0.001). Hb and Hct levels were significantly lower in subjects in the highest quartile of UAE compared to those in lowest quartile (135 vs 140 g/L, and 0.40 vs 0.41 L/L, respectively, for all p=0.03). Finally, those with mildly impaired eGFR had significantly lower lev- els of Hb, Hct and E compared to those with normal eGFR or hyperfiltrating subjects (133 vs 140 g/L, 0.38 vs 0.41 L/L, and 4.4 vs 4.7x10 12 /L, respectively, for all p=0.01). We have detected that interplay between RBC and renal function pa- rameters occurs even in type 1 diabetic patients with normal or mildly impaired renal function.

Ključne riječi
type 1 diabetes; renal function; anemia; hemoglobin

Hrčak ID: 118217

URI
https://hrcak.srce.hr/118217

Posjeta: 219 *