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The Role of C-Fos Protein, Somatostatin and Neuropeptide Y in the Pathogenesis of Ischemic Brain Injuries Based on Animal Model of Cerebral Ischemia

Aleksandar A. Jovanović ; University of Belgrade, School of Medicine, Belgrade, Serbia
Siniša S. Babović ; University of Novi Sad, School of Medicine, Institute of Anatomy, Novi Sad, Serbia
Aleksandar Damjanović ; University of Belgrade, School of Medicine, Belgrade, Serbia
Laslo Puškaš ; University of Belgrade, School of Medicine, Institute of Anatomy, Belgrade, Serbia
Dijana Lazić ; Faculty for Special Education and Rehabilitation, Belgrade, Serbia
Tijana Cvetić ; Clinic for Psychiatry, Clinical Centre of Serbia, Belgrade, Serbia
Miroslava Jašović-Gašić ; University of Belgrade, School of Medicine, Belgrade, Serbia

Puni tekst: engleski, pdf (316 KB) str. 847-852 preuzimanja: 208* citiraj
APA 6th Edition
A. Jovanović, A., S. Babović, S., Damjanović, A., Puškaš, L., Lazić, D., Cvetić, T. i Jašović-Gašić, M. (2013). The Role of C-Fos Protein, Somatostatin and Neuropeptide Y in the Pathogenesis of Ischemic Brain Injuries Based on Animal Model of Cerebral Ischemia. Collegium antropologicum, 37 (3), 847-852. Preuzeto s https://hrcak.srce.hr/118280
MLA 8th Edition
A. Jovanović, Aleksandar, et al. "The Role of C-Fos Protein, Somatostatin and Neuropeptide Y in the Pathogenesis of Ischemic Brain Injuries Based on Animal Model of Cerebral Ischemia." Collegium antropologicum, vol. 37, br. 3, 2013, str. 847-852. https://hrcak.srce.hr/118280. Citirano 18.09.2020.
Chicago 17th Edition
A. Jovanović, Aleksandar, Siniša S. Babović, Aleksandar Damjanović, Laslo Puškaš, Dijana Lazić, Tijana Cvetić i Miroslava Jašović-Gašić. "The Role of C-Fos Protein, Somatostatin and Neuropeptide Y in the Pathogenesis of Ischemic Brain Injuries Based on Animal Model of Cerebral Ischemia." Collegium antropologicum 37, br. 3 (2013): 847-852. https://hrcak.srce.hr/118280
Harvard
A. Jovanović, A., et al. (2013). 'The Role of C-Fos Protein, Somatostatin and Neuropeptide Y in the Pathogenesis of Ischemic Brain Injuries Based on Animal Model of Cerebral Ischemia', Collegium antropologicum, 37(3), str. 847-852. Preuzeto s: https://hrcak.srce.hr/118280 (Datum pristupa: 18.09.2020.)
Vancouver
A. Jovanović A, S. Babović S, Damjanović A, Puškaš L, Lazić D, Cvetić T i sur. The Role of C-Fos Protein, Somatostatin and Neuropeptide Y in the Pathogenesis of Ischemic Brain Injuries Based on Animal Model of Cerebral Ischemia. Collegium antropologicum [Internet]. 2013 [pristupljeno 18.09.2020.];37(3):847-852. Dostupno na: https://hrcak.srce.hr/118280
IEEE
A. A. Jovanović, et al., "The Role of C-Fos Protein, Somatostatin and Neuropeptide Y in the Pathogenesis of Ischemic Brain Injuries Based on Animal Model of Cerebral Ischemia", Collegium antropologicum, vol.37, br. 3, str. 847-852, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/118280. [Citirano: 18.09.2020.]

Sažetak
The aim of this study was to define all the areas of changes in expression of nuclear c-Fos protein (c-Fos), cytoplasmic somatostatin (SS) and neuropeptide Y (NPY) in rat brain during experimental ischemia. Using the immunohistoche- mical method, brain mapping (based on the atlas by Paxinos & Watson) of immunoreactivity for c-Fos, SS and NPY in 39 rats, was studied in telencephalon, diencephalon and midbrain after resistant and transitory ischemia. The first ex- perimental group (R group) was exposed to resistant ischemia by occlusion (10 minutes) of four vessels according to the Pulsinelli method. The second group was first exposed to transitory (4 minutes) ischemia (preconditioning) and, after 72 hours, to total ischemia as in the R group. There was a statistical difference between the R and T group in the c-Fos reac- tion, especially in the parietofrontal cortex, anterior amygdaloid area, claustrum, reuniens nucleus and suprachiasmatic nucleus. The dominant immunohistochemical reactivity was found for c-Fos protein, and the most reactive in terms of co-localization of c-Fos with SS and NPY was periventricular area of hypothalamus. The mapping showed that both, phylogenetically new as well as phylogenetically older brain structures reacted immunohistochemically. The results of our study, regarding the impact of preconditioning with a short period of ischemia on c-Fos activity and co-localization of c-Fos with SS and NPY immunoreactivity, showed the need for future studies of brain neuropeptides related to re- gional and time effects, and indicated brain structures which may require pharmacological targeting to achieve neuro- protective level of proto-oncogene activity in populations at risk.

Ključne riječi
brain; transitory ischemia; proto-oncogenes; c-Fos; somatostatin; neuropeptide Y

Hrčak ID: 118280

URI
https://hrcak.srce.hr/118280

Posjeta: 365 *