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Original scientific paper

Do IL-1B and IL-1RN Modulate Chronic Low Back Pain in Patients with Post-Traumatic Stress Disorder?

Zoran Lončar ; University of Zagreb, University Hospital Center »Sestre Milosrdnice«, Cinic for Traumatology, Zagreb, Croatia
Goran Čurić ; University »J. J. Strossmayer«, School of Medicine, Laboratory for DNA analysis, Osijek, Croatia
Ana Havelka Meštrović ; University of Zagreb, University Hospital Dubrava, Psychiatry Clinic, Zagreb, Croatia
Vlatko Mićković ; Institute for Anthropological Research, Zagreb, Croatia
Morana Bilić ; University of Applied Health Studies, Zagreb, Croatia

Fulltext: english, pdf (92 KB) pages 1237-1244 downloads: 180* cite
APA 6th Edition
Lončar, Z., Čurić, G., Havelka Meštrović, A., Mićković, V. & Bilić, M. (2013). Do IL-1B and IL-1RN Modulate Chronic Low Back Pain in Patients with Post-Traumatic Stress Disorder?. Collegium antropologicum, 37 (4), 1237-1244. Retrieved from https://hrcak.srce.hr/118374
MLA 8th Edition
Lončar, Zoran, et al. "Do IL-1B and IL-1RN Modulate Chronic Low Back Pain in Patients with Post-Traumatic Stress Disorder?." Collegium antropologicum, vol. 37, no. 4, 2013, pp. 1237-1244. https://hrcak.srce.hr/118374. Accessed 24 Oct. 2020.
Chicago 17th Edition
Lončar, Zoran, Goran Čurić, Ana Havelka Meštrović, Vlatko Mićković and Morana Bilić. "Do IL-1B and IL-1RN Modulate Chronic Low Back Pain in Patients with Post-Traumatic Stress Disorder?." Collegium antropologicum 37, no. 4 (2013): 1237-1244. https://hrcak.srce.hr/118374
Harvard
Lončar, Z., et al. (2013). 'Do IL-1B and IL-1RN Modulate Chronic Low Back Pain in Patients with Post-Traumatic Stress Disorder?', Collegium antropologicum, 37(4), pp. 1237-1244. Available at: https://hrcak.srce.hr/118374 (Accessed 24 October 2020)
Vancouver
Lončar Z, Čurić G, Havelka Meštrović A, Mićković V, Bilić M. Do IL-1B and IL-1RN Modulate Chronic Low Back Pain in Patients with Post-Traumatic Stress Disorder?. Collegium antropologicum [Internet]. 2013 [cited 2020 October 24];37(4):1237-1244. Available from: https://hrcak.srce.hr/118374
IEEE
Z. Lončar, G. Čurić, A. Havelka Meštrović, V. Mićković and M. Bilić, "Do IL-1B and IL-1RN Modulate Chronic Low Back Pain in Patients with Post-Traumatic Stress Disorder?", Collegium antropologicum, vol.37, no. 4, pp. 1237-1244, 2013. [Online]. Available: https://hrcak.srce.hr/118374. [Accessed: 24 October 2020]

Abstracts
The aim of this study was to analyze the association between single nucleotide polymorphism (SNP) in IL1B (rs1143 634) and IL1RN (rs2234677) with chronic low back pain (LBP) in chronic post-traumatic stress disorder (PTSD). A total of 406 war veterans from 1991–1995 war in Croatia participated in this study. They were divided into four groups, ac- cording to psychiatric interview, psychometric testing and the presence of LBP , verified by the imaging of lumbar area, into: (i) war veterans suffering from PTSD and LBP (N=102), (ii) war veterans suffering from PTSD only (N=108), (iii) war veterans suffering from LBP only (N=99) and (iv) healthy controls (N=97). Each subject provided a blood sample for IL1B and IL1RN polymorphism testing. We found no association of rs1143634 in IL1-B with LBP . Permutation test showed significant association of rs1143634 in IL1-RN with LBP group and presence of wild type allele A was protective in LBP group. The same SNP (rs1143634) in IL1-B was associated with the intensity of pain. No other associations were observed between these two markers and self-reported measures evaluating PTSD and pain symptoms. These results suggest the potential role of cytokine network in the pathogenesis of chronic PTSD and LBP , although the direct caus- ative pathway remains unclear. The alteration of cytokine network on the level of the brain, spinal medulla and the spine may be responsible for modulation of pain and the occurrence of LBP.

Keywords
PTSD; chronic pain; single nucleotide polymorphism; IL-1B; IL-1RN

Hrčak ID: 118374

URI
https://hrcak.srce.hr/118374

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