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Acta Pharmaceutica, Vol. 57 No. 3, 2007.

Kratko priopćenje
https://doi.org/10.2478/v10007-007-0028-2

Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method

HARESH M. PATEL
BHANUBHAI N. SUHAGIA
SHAILESH A. SHAH
ISHWAR SINH RATHOD
VIJAY K. PARMAR

Puni tekst: engleski, pdf (157 KB) str. 351-359 preuzimanja: 1.846* citiraj
APA 6th Edition
PATEL, H.M., SUHAGIA, B.N., SHAH, S.A., RATHOD, I.S. i PARMAR, V.K. (2007). Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method. Acta Pharmaceutica, 57 (3), 351-359. https://doi.org/10.2478/v10007-007-0028-2
MLA 8th Edition
PATEL, HARESH M., et al. "Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method." Acta Pharmaceutica, vol. 57, br. 3, 2007, str. 351-359. https://doi.org/10.2478/v10007-007-0028-2. Citirano 27.05.2019.
Chicago 17th Edition
PATEL, HARESH M., BHANUBHAI N. SUHAGIA, SHAILESH A. SHAH, ISHWAR SINH RATHOD i VIJAY K. PARMAR. "Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method." Acta Pharmaceutica 57, br. 3 (2007): 351-359. https://doi.org/10.2478/v10007-007-0028-2
Harvard
PATEL, H.M., et al. (2007). 'Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method', Acta Pharmaceutica, 57(3), str. 351-359. doi: https://doi.org/10.2478/v10007-007-0028-2
Vancouver
PATEL HM, SUHAGIA BN, SHAH SA, RATHOD IS, PARMAR VK. Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method. Acta Pharm. [Internet]. 2007 [pristupljeno 27.05.2019.];57(3):351-359. doi: https://doi.org/10.2478/v10007-007-0028-2
IEEE
H.M. PATEL, B.N. SUHAGIA, S.A. SHAH, I.S. RATHOD i V.K. PARMAR, "Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method", Acta Pharmaceutica, vol.57, br. 3, str. 351-359, 2007. [Online]. doi: https://doi.org/10.2478/v10007-007-0028-2

Sažetak
The binary system of etoricoxib with β-cyclodextrin (β-CD) was prepared by the kneading method. Drug-cyclodextrin interactions in solution were investigated by the phase solubility analysis. Differential scanning calorimetry, infrared spectroscopy, powder X-ray diffractometry and microscopic study were used to characterize the solid state of all binary systems, whereas their dissolution properties were evaluated according to the USP XXIII paddle method. The results indicate partial interaction of the drug with β-CD in the physical mixture and complete interaction in the kneaded complex. The dissolution of etoricoxib was notably increased as compared to pure drug as well as its physical mixture. The complex showed more than 75% drug released in 30 min.

Ključne riječi
etoricoxib; cyclodextrin; complexation; kneading method

Hrčak ID: 12065

URI
https://hrcak.srce.hr/12065

[hrvatski]

Posjeta: 2.214 *