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Asymmetric membrane capsule for osmotic delivery of flurbiprofen
PRATIM K. CHOUDHURY
MAHENDRA S. RANAWAT
MOUSUMI K. PILLAI
CHETAN S. CHAUHAN
Puni tekst: engleski, pdf (80 KB)
APA 6th Edition
CHOUDHURY, P.K., RANAWAT, M.S., PILLAI, M.K. i CHAUHAN, C.S. (2007). Asymmetric membrane capsule for osmotic delivery of flurbiprofen. Acta Pharmaceutica, 57 (3), 343-350. https://doi.org/10.2478/v10007-007-0027-3
MLA 8th Edition
CHOUDHURY, PRATIM K., et al. "Asymmetric membrane capsule for osmotic delivery of flurbiprofen." Acta Pharmaceutica, vol. 57, br. 3, 2007, str. 343-350. https://doi.org/10.2478/v10007-007-0027-3. Citirano 24.02.2019.
Chicago 17th Edition
CHOUDHURY, PRATIM K., MAHENDRA S. RANAWAT, MOUSUMI K. PILLAI i CHETAN S. CHAUHAN. "Asymmetric membrane capsule for osmotic delivery of flurbiprofen." Acta Pharmaceutica 57, br. 3 (2007): 343-350. https://doi.org/10.2478/v10007-007-0027-3
CHOUDHURY, P.K., et al. (2007). 'Asymmetric membrane capsule for osmotic delivery of flurbiprofen', Acta Pharmaceutica, 57(3), str. 343-350. doi: https://doi.org/10.2478/v10007-007-0027-3
CHOUDHURY PK, RANAWAT MS, PILLAI MK, CHAUHAN CS. Asymmetric membrane capsule for osmotic delivery of flurbiprofen. Acta Pharm. [Internet]. 2007 [pristupljeno 24.02.2019.];57(3):343-350. doi: https://doi.org/10.2478/v10007-007-0027-3
P.K. CHOUDHURY, M.S. RANAWAT, M.K. PILLAI i C.S. CHAUHAN, "Asymmetric membrane capsule for osmotic delivery of flurbiprofen", Acta Pharmaceutica, vol.57, br. 3, str. 343-350, 2007. [Online]. doi: https://doi.org/10.2478/v10007-007-0027-3
An asymmetric membrane capsule of cellulose acetate for osmotic delivery of flurbiprofen has been developed and influence of osmogents and solubilizing agent on in vitro drug release were evaluated. The capsule membrane was prepared by the phase inversion technique. To ensure the osmotic delivery of drug, two approaches were adopted: (i) the drug was encapsulated with osmogents like sodium chloride and mannitol to increase the osmotic pressure of the core, and (ii) the drug was encapsulated with sodium lauryl sulfate in the core of the formulation to increase the solubility and thus its osmotic pressure. Scanning electron microscopy of the membrane confirmed its porous, dense asymmetric nature. Dye test revealed in situ pore formation. The in vitro release study showed that as the proportion of osmogent and solubilizing agent was increased the release rate also increased. A good correlation was observed between the zero-order rate constant and the amount of the osmogent and solubilizing agent used.
osmotic delivery; asymmetric membrane; cellulose acetate; flurbiprofen; osmogent
Hrčak ID: 12066
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