Izvorni znanstveni članak

Bcl-2 and Bax immunoreactivity in placentas from pregnancies complicated with intrauterine growth restriction and hypertension

MARINA KOS ; 1_Clinical Department of Pathology „Ljudevit Jurak”, Clinical Hospital Center „Sestre milosrdnice”, Vinogradska 29, 10 000 Zagreb; 2_Institue of Pathology, Medical School, University of Zagreb, Zagreb, Croatia
EDUARD MATKOVICH ; Clinical Department of Pathology „Ljudevit Jurak”, Clinical Hospital Center „Sestre milosrdnice”, Vinogradska 29, 10 000 Zagreb

Sažetak

Because placental apoptosis associated protein imbalance is thought to contribute to the pathogenesis of intrauterine growth restriction (IUGR) and preeclampsia (PE), morphological features and expression of Bcl-2 and Bax were studied on samples from 10 human placentas from pregnancies complicated with IUGR and PE and 10 placentas from uncomplicated term pregnancies.

In 9/10 placentas from the IUGR/PE group, the findings were consistent with hypoxic damage and in 1/10 placentas chronic villitis was found. In both groups Bax showed strong diffuse expression (3+) in amnionic epithelium, blood vessel wall and endothelium in the chorionic plate and placental villi and the villous stroma in all placentas. The extravillous trophoblast (EVT) in the basal decidua showed 3+ Bax expression in 8/10 placentas and 2+ expression in 2/10 placentas in both groups. In the IUGR/PE group
the Bax expression in both cyto (CT) and syncytiotrophoblast (ST), was 3+ in 8/10 placentas, and 2+ in 2/10 placentas. In the control group Bax expression was 3+ in both CT and ST in all 10 placentas. The 3+ Bcl-2 expression in both groups was found only in CT and ST. The syncytial knots in both groups showed 3+ positivity for Bax and Bcl-2. These findings do not confirm other authors’ findings about the increased expression of proapoptotic factors in the third trimester placentas with IUGR/PE, and the conclusion is that for the pathogenesis of IUGR and PE, the attention should be shifted to
inappropriate apoptosis during the process of implantation.

Ključne riječi

apoptosis; placenta; IUGR; preeclampsia

Hrčak ID:

126356

URI

https://hrcak.srce.hr/126356

Datum izdavanja:

31.7.2014.

Posjeta: 1.223 *