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Izvorni znanstveni članak
https://doi.org/10.2478/10004-1254-65-2014-2494
A unique pattern of bisphenol A effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44
Katsuhiko Warita
; Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan
Tomoko Mitsuhashi
; Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, USA
Nobuhiko Hoshi
; Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe, Japan
Ken-ichi Ohta
; Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan
Shingo Suzuki
; Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan
Yoshiki Takeuchi
; Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan
Takanori Miki
; Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan
| Puni tekst: engleski, pdf (343 KB) | str. 293-298 | citiraj | |
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APA 6th Edition Warita, K., Mitsuhashi, T., Hoshi, N., Ohta, K., Suzuki, S., Takeuchi, Y. i Miki, T. (2014). A unique pattern of bisphenol A effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44. Arhiv za higijenu rada i toksikologiju, 65 (3), 293-298. https://doi.org/10.2478/10004-1254-65-2014-2494 MLA 8th Edition Warita, Katsuhiko, et al. "A unique pattern of bisphenol A effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44." Arhiv za higijenu rada i toksikologiju, vol. 65, br. 3, 2014, str. 293-298. https://doi.org/10.2478/10004-1254-65-2014-2494. Citirano 07.03.2021. Chicago 17th Edition Warita, Katsuhiko, Tomoko Mitsuhashi, Nobuhiko Hoshi, Ken-ichi Ohta, Shingo Suzuki, Yoshiki Takeuchi i Takanori Miki. "A unique pattern of bisphenol A effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44." Arhiv za higijenu rada i toksikologiju 65, br. 3 (2014): 293-298. https://doi.org/10.2478/10004-1254-65-2014-2494 Harvard Warita, K., et al. (2014). 'A unique pattern of bisphenol A effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44', Arhiv za higijenu rada i toksikologiju, 65(3), str. 293-298. https://doi.org/10.2478/10004-1254-65-2014-2494 Vancouver Warita K, Mitsuhashi T, Hoshi N, Ohta K, Suzuki S, Takeuchi Y i sur. A unique pattern of bisphenol A effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44. Arh Hig Rada Toksikol. [Internet]. 2014 [pristupljeno 07.03.2021.];65(3):293-298. https://doi.org/10.2478/10004-1254-65-2014-2494 IEEE K. Warita, et al., "A unique pattern of bisphenol A effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44", Arhiv za higijenu rada i toksikologiju, vol.65, br. 3, str. 293-298, 2014. [Online]. https://doi.org/10.2478/10004-1254-65-2014-2494 |
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Sažetak
We investigated the toxicity of bisphenol A (BPA) by determining the gene expression of nerve growth factor (Ngf) in the embryonic mouse cell line mHypoE-N44 derived from the hypothalamus exposed to BPA dose range between 0.02 and 200 μmol L-1 for 3 h. Ngf mRNA levels decreased in a dose-dependent manner, with significant reductions observed in the 2 to 50 μmol L-1 BPA treatment groups compared to controls. However, at 100 to 200 μmol L-1 the Ngf mRNA gradually increased and was significantly higher than control, while the expression of the apoptosis-related genes Caspase 3 and transformation-related protein 73 decreased significantly. These results suggest that in an embryonic hypothalamic cell line the higher doses of BPA induce a unique pattern of Ngf gene expression and that BPA has the potential to suppress apoptosis essential for early-stage brain development.
Ključne riječi
Caspase 3; developmental toxicity; foetal hypothalamus; nerve growth factor; transformation-related protein 73
Hrčak ID: 126612
URI
https://hrcak.srce.hr/126612
Moj profil
Srce