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Chemistry of Torasemide. Molecular and Crystal Structure of New Polymorph N

Aleksandar Danilovski ; PLIVA d. d., Research and Development, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia
Darko Filić ; PLIVA d. d., Research and Development, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia
Marina Orešić ; PLIVA d. d., Research and Development, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia
Miljenko Dumić ; PLIVA d. d., Research and Development, Prilaz baruna Filipovića 25, HR-10000 Zagreb, Croatia

Puni tekst: engleski, pdf (358 KB) str. 103-120 preuzimanja: 406* citiraj
APA 6th Edition
Danilovski, A., Filić, D., Orešić, M. i Dumić, M. (2001). Chemistry of Torasemide. Molecular and Crystal Structure of New Polymorph N. Croatica Chemica Acta, 74 (1), 103-120. Preuzeto s https://hrcak.srce.hr/131779
MLA 8th Edition
Danilovski, Aleksandar, et al. "Chemistry of Torasemide. Molecular and Crystal Structure of New Polymorph N." Croatica Chemica Acta, vol. 74, br. 1, 2001, str. 103-120. https://hrcak.srce.hr/131779. Citirano 28.02.2021.
Chicago 17th Edition
Danilovski, Aleksandar, Darko Filić, Marina Orešić i Miljenko Dumić. "Chemistry of Torasemide. Molecular and Crystal Structure of New Polymorph N." Croatica Chemica Acta 74, br. 1 (2001): 103-120. https://hrcak.srce.hr/131779
Harvard
Danilovski, A., et al. (2001). 'Chemistry of Torasemide. Molecular and Crystal Structure of New Polymorph N', Croatica Chemica Acta, 74(1), str. 103-120. Preuzeto s: https://hrcak.srce.hr/131779 (Datum pristupa: 28.02.2021.)
Vancouver
Danilovski A, Filić D, Orešić M, Dumić M. Chemistry of Torasemide. Molecular and Crystal Structure of New Polymorph N. Croatica Chemica Acta [Internet]. 2001 [pristupljeno 28.02.2021.];74(1):103-120. Dostupno na: https://hrcak.srce.hr/131779
IEEE
A. Danilovski, D. Filić, M. Orešić i M. Dumić, "Chemistry of Torasemide. Molecular and Crystal Structure of New Polymorph N", Croatica Chemica Acta, vol.74, br. 1, str. 103-120, 2001. [Online]. Dostupno na: https://hrcak.srce.hr/131779. [Citirano: 28.02.2021.]

Sažetak
It is known from literature that torasemide, generic name for N1-isopropyl-N3-[4-(3-methylphenylamino)-3-pyridylsulphonyl]urea, can have two polymorphic forms, denoted as T-I and T-II. A novel, third polymorph N of torasemide, T-N has been discovered and fully characterised. It crystallises in the centrosymmetric monoclinic space group P21/c with two crystallographically independent molecules, which differ primarily in their different phenyl ring and A1-isopropyl side chain orientations. Both independent molecules, i.e. conformations, can adopt a zwitter-ionic structure. The new polymorph of torasemide is characterised by a considerably complex three-dimensional hydrogen-bonding network that spans ali over the crystal unit cell. The crystal packing of T-N is rather crowded, dense and compact. It is pointed out that the degree of crystal structure diversity of the existing torasemide polymorphs is considerably high, with different conformational properties of distinct torasemide molecules in its asymmetric unit.

Ključne riječi
torasemide; pyridylsulphonylurea; polymorphism; X-ray diffraction; conformation

Hrčak ID: 131779

URI
https://hrcak.srce.hr/131779

Posjeta: 556 *