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Protective Effects of Met-enkephalin on Alcohol Induced Gastric Lesions

Paško Konjevoda ; Department of Pharmacology, Zagreb University School of Medicine, Salata 2, 10000 Zagreb, Croatia
Nikola Štambuk ; Rudjer Bošković Institute, Bijenička 54, 10001 Zagreb, Croatia
Dražen Vikić-Topić ; Rudjer Bošković Institute, Bijenička 54, 10001 Zagreb, Croatia
Alenka Boban-Blagaić ; MOLO dd, Maksimirska 21, 10000 Zagreb, Croatia
Smiljka Vikić-Topić ; Pliva Research Institute, Baruna Filipovića 25, 10000 Zagreb, Croatia
Vladimir Mrljak ; Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia
Josip Pavan ; Clinical Hospital Dubrava, Avenija Gojka Šuška bb, 10000 Zagreb, Croatia
Pero Ramadan ; Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia
Zdenko Biđin ; Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia

Puni tekst: engleski, pdf (89 KB) str. 1111-1121 preuzimanja: 191* citiraj
APA 6th Edition
Konjevoda, P., Štambuk, N., Vikić-Topić, D., Boban-Blagaić, A., Vikić-Topić, S., Mrljak, V., ... Biđin, Z. (2000). Protective Effects of Met-enkephalin on Alcohol Induced Gastric Lesions. Croatica Chemica Acta, 73 (4), 1111-1121. Preuzeto s https://hrcak.srce.hr/131992
MLA 8th Edition
Konjevoda, Paško, et al. "Protective Effects of Met-enkephalin on Alcohol Induced Gastric Lesions." Croatica Chemica Acta, vol. 73, br. 4, 2000, str. 1111-1121. https://hrcak.srce.hr/131992. Citirano 23.06.2021.
Chicago 17th Edition
Konjevoda, Paško, Nikola Štambuk, Dražen Vikić-Topić, Alenka Boban-Blagaić, Smiljka Vikić-Topić, Vladimir Mrljak, Josip Pavan, Pero Ramadan i Zdenko Biđin. "Protective Effects of Met-enkephalin on Alcohol Induced Gastric Lesions." Croatica Chemica Acta 73, br. 4 (2000): 1111-1121. https://hrcak.srce.hr/131992
Harvard
Konjevoda, P., et al. (2000). 'Protective Effects of Met-enkephalin on Alcohol Induced Gastric Lesions', Croatica Chemica Acta, 73(4), str. 1111-1121. Preuzeto s: https://hrcak.srce.hr/131992 (Datum pristupa: 23.06.2021.)
Vancouver
Konjevoda P, Štambuk N, Vikić-Topić D, Boban-Blagaić A, Vikić-Topić S, Mrljak V i sur. Protective Effects of Met-enkephalin on Alcohol Induced Gastric Lesions. Croatica Chemica Acta [Internet]. 2000 [pristupljeno 23.06.2021.];73(4):1111-1121. Dostupno na: https://hrcak.srce.hr/131992
IEEE
P. Konjevoda, et al., "Protective Effects of Met-enkephalin on Alcohol Induced Gastric Lesions", Croatica Chemica Acta, vol.73, br. 4, str. 1111-1121, 2000. [Online]. Dostupno na: https://hrcak.srce.hr/131992. [Citirano: 23.06.2021.]

Sažetak
The model of ethanol induced gastric lesions is useful in the evaluation of gastric cytoprotection. We used it to measure cytoprotective effects of two neuropeptides, Met-enkephalin (Peptid-M, LUPEX®) and α-melanocyte stimulating hormone (α-MSH). Both peptides exhibited significant and synergistic cytoprotective effects. The best therapeutic efficacy was obtained with Met-enkephalin and α-MSH mixture 3-5 : 1. Significant cytoprotective action on ethanol induced lesions was also observed by means of two thymus peptide immunomodulators, Thymus Peptide C® and JAN 50®. Thymus Peptide C® exhibited a more significant synergistic effect with Met-enkephalin than JAN 50®. In addition to the cytoprotection of rat gastric mucosa, Met-enkephalin also induced statistically significant and dose dependent Straub tail response versus control in miče. Haloperidol, naloxone and Peptide-D antagonised its effects. NMR spectrospic data supported molecular interaction of Met-enkephalin and haloperidol, while neutralization of Met-enkephalin induced Straub tail response by means of Peptide-D indicated the presence of new non-opioid (naloxone independent) receptor system containing Peptide-D sequence (calpastatin 201-205 aa).

Ključne riječi
Met-enkephalin; LUPEX®; α -MSH; ethanol; gastric lesions; peptide-D; cytoprotection; Straub phenomenon; haloperidol; NMR; Thymus Peptide C®; JAN 50®

Hrčak ID: 131992

URI
https://hrcak.srce.hr/131992

Posjeta: 367 *