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Some Comments on the Crystallography and the Evolution of the Catalytic Structure in Some Serine Hydrolases

Eleanor Dodson ; Department of Chemistry, University of York, York YO10 5DD, UK
Guy Dodson ; Department of Chemistry, University of York, York YO10 5DD, UK

Puni tekst: engleski, pdf (206 KB) str. 209-220 preuzimanja: 111* citiraj
APA 6th Edition
Dodson, E. i Dodson, G. (1999). Some Comments on the Crystallography and the Evolution of the Catalytic Structure in Some Serine Hydrolases. Croatica Chemica Acta, 72 (2-3), 209-220. Preuzeto s https://hrcak.srce.hr/132157
MLA 8th Edition
Dodson, Eleanor i Guy Dodson. "Some Comments on the Crystallography and the Evolution of the Catalytic Structure in Some Serine Hydrolases." Croatica Chemica Acta, vol. 72, br. 2-3, 1999, str. 209-220. https://hrcak.srce.hr/132157. Citirano 08.04.2020.
Chicago 17th Edition
Dodson, Eleanor i Guy Dodson. "Some Comments on the Crystallography and the Evolution of the Catalytic Structure in Some Serine Hydrolases." Croatica Chemica Acta 72, br. 2-3 (1999): 209-220. https://hrcak.srce.hr/132157
Harvard
Dodson, E., i Dodson, G. (1999). 'Some Comments on the Crystallography and the Evolution of the Catalytic Structure in Some Serine Hydrolases', Croatica Chemica Acta, 72(2-3), str. 209-220. Preuzeto s: https://hrcak.srce.hr/132157 (Datum pristupa: 08.04.2020.)
Vancouver
Dodson E, Dodson G. Some Comments on the Crystallography and the Evolution of the Catalytic Structure in Some Serine Hydrolases. Croatica Chemica Acta [Internet]. 1999 [pristupljeno 08.04.2020.];72(2-3):209-220. Dostupno na: https://hrcak.srce.hr/132157
IEEE
E. Dodson i G. Dodson, "Some Comments on the Crystallography and the Evolution of the Catalytic Structure in Some Serine Hydrolases", Croatica Chemica Acta, vol.72, br. 2-3, str. 209-220, 1999. [Online]. Dostupno na: https://hrcak.srce.hr/132157. [Citirano: 08.04.2020.]

Sažetak
X-ray analysis has provided a 3-dimensional structural basis through which the complex processes of biochemistry and biology can be investigated and understood. The crystallographic studies on the serine hydrolases have provided accurate structures for many of the enzyme families and have shown that although the families evolved independently, their active atoms in their catalytic structures have equivalent stereochemistry. There has also been remarkable variation in the amino acid composition of the catalytic structures. Analysis has shown that their essential catalytic chemistry is achieved through the interactions of carboxyl or carbonyl oxygens, a base and a potential nucleophile. Finally the evolutionary changes in some enzyme families, such as the Ntn-hydrolases, are so extensive that their evolutionary relationships can only be detected by comparisons of their 3-dimensional structures. Thus X-ray analysis gives the biologist Chemical, functional and evolutionary insight into protein molecules.

Ključne riječi
serine proteases; serine hydrolases; X-ray crystallography; catalytic triad; molecular evolution; nucleophilic attack; amidase; esterase; Ntn-hydrolases

Hrčak ID: 132157

URI
https://hrcak.srce.hr/132157

Posjeta: 211 *