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Epitope Mapping of Macrolide Antibiotics to Bovine Serum Albumin by Saturation Transfer Difference NMR Spectroscopy

Predrag Novak
Predrag Tepeš
Vedrana Lazić

Puni tekst: engleski, pdf (361 KB) str. 211-216 preuzimanja: 779* citiraj
APA 6th Edition
Novak, P., Tepeš, P. i Lazić, V. (2007). Epitope Mapping of Macrolide Antibiotics to Bovine Serum Albumin by Saturation Transfer Difference NMR Spectroscopy. Croatica Chemica Acta, 80 (2), 211-216. Preuzeto s https://hrcak.srce.hr/12854
MLA 8th Edition
Novak, Predrag, et al. "Epitope Mapping of Macrolide Antibiotics to Bovine Serum Albumin by Saturation Transfer Difference NMR Spectroscopy." Croatica Chemica Acta, vol. 80, br. 2, 2007, str. 211-216. https://hrcak.srce.hr/12854. Citirano 12.12.2019.
Chicago 17th Edition
Novak, Predrag, Predrag Tepeš i Vedrana Lazić. "Epitope Mapping of Macrolide Antibiotics to Bovine Serum Albumin by Saturation Transfer Difference NMR Spectroscopy." Croatica Chemica Acta 80, br. 2 (2007): 211-216. https://hrcak.srce.hr/12854
Harvard
Novak, P., Tepeš, P., i Lazić, V. (2007). 'Epitope Mapping of Macrolide Antibiotics to Bovine Serum Albumin by Saturation Transfer Difference NMR Spectroscopy', Croatica Chemica Acta, 80(2), str. 211-216. Preuzeto s: https://hrcak.srce.hr/12854 (Datum pristupa: 12.12.2019.)
Vancouver
Novak P, Tepeš P, Lazić V. Epitope Mapping of Macrolide Antibiotics to Bovine Serum Albumin by Saturation Transfer Difference NMR Spectroscopy. Croatica Chemica Acta [Internet]. 2007 [pristupljeno 12.12.2019.];80(2):211-216. Dostupno na: https://hrcak.srce.hr/12854
IEEE
P. Novak, P. Tepeš i V. Lazić, "Epitope Mapping of Macrolide Antibiotics to Bovine Serum Albumin by Saturation Transfer Difference NMR Spectroscopy", Croatica Chemica Acta, vol.80, br. 2, str. 211-216, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/12854. [Citirano: 12.12.2019.]

Sažetak
Saturation transfer difference NMR spectroscopy was employed to characterize epitopes of macrolide antibiotics, azithromycin, oleandomycin and telithromycin binding to bovine serum albumin. The structural parts of azithromycin and oleandomycin in intimate contact with bovine serum albumin were found to be similar while those of telithromycin showed similarities but also some differences. The latter were mostly due to different structural elements of antibiotics that interact with the protein, especially the alkyl-heteroaryl side chain in telithromycin and cladinose and desosamine sugars in azithromycin and oleandomycin. The epitope maps as
determined in this study can contribute to better understanding of the overall bioactivity of macrolides.

Ključne riječi
STD NMR spectroscopy; macrolide antibiotics; albumin; epitope mapping

Hrčak ID: 12854

URI
https://hrcak.srce.hr/12854

Posjeta: 1.092 *