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Theoretical Studies for Molecular Modeling of New Camptothecin Analogues

Sachiko Aida-Hyugaji
Hiroshi Nakagawa
Jumma Nomura
Minoru Sakurai
Umpei Nagashima
Toshihisa Ishikawa

Puni tekst: engleski, pdf (202 KB) str. 277-281 preuzimanja: 724* citiraj
APA 6th Edition
Aida-Hyugaji, S., Nakagawa, H., Nomura, J., Sakurai, M., Nagashima, U. i Ishikawa, T. (2007). Theoretical Studies for Molecular Modeling of New Camptothecin Analogues. Croatica Chemica Acta, 80 (2), 277-281. Preuzeto s https://hrcak.srce.hr/12868
MLA 8th Edition
Aida-Hyugaji, Sachiko, et al. "Theoretical Studies for Molecular Modeling of New Camptothecin Analogues." Croatica Chemica Acta, vol. 80, br. 2, 2007, str. 277-281. https://hrcak.srce.hr/12868. Citirano 19.01.2020.
Chicago 17th Edition
Aida-Hyugaji, Sachiko, Hiroshi Nakagawa, Jumma Nomura, Minoru Sakurai, Umpei Nagashima i Toshihisa Ishikawa. "Theoretical Studies for Molecular Modeling of New Camptothecin Analogues." Croatica Chemica Acta 80, br. 2 (2007): 277-281. https://hrcak.srce.hr/12868
Harvard
Aida-Hyugaji, S., et al. (2007). 'Theoretical Studies for Molecular Modeling of New Camptothecin Analogues', Croatica Chemica Acta, 80(2), str. 277-281. Preuzeto s: https://hrcak.srce.hr/12868 (Datum pristupa: 19.01.2020.)
Vancouver
Aida-Hyugaji S, Nakagawa H, Nomura J, Sakurai M, Nagashima U, Ishikawa T. Theoretical Studies for Molecular Modeling of New Camptothecin Analogues. Croatica Chemica Acta [Internet]. 2007 [pristupljeno 19.01.2020.];80(2):277-281. Dostupno na: https://hrcak.srce.hr/12868
IEEE
S. Aida-Hyugaji, H. Nakagawa, J. Nomura, M. Sakurai, U. Nagashima i T. Ishikawa, "Theoretical Studies for Molecular Modeling of New Camptothecin Analogues", Croatica Chemica Acta, vol.80, br. 2, str. 277-281, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/12868. [Citirano: 19.01.2020.]

Sažetak
Irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino carbonyloxycamptothecin: CPT-11) is a widely used potent antitumor drug that is developed based on camptothecin. However, overexpression of ABCG2 (BCRP/MXR/ABCP) confers cancer cells resistance to SN-38, that is, the active metabolite of irinotecan. In the present study to develop a platform for the molecular modeling to circumvent cancer drug resistance associated with ABCG2, we have characterized a total of fourteen new SN-38 analogues by some typical properties, which were evaluated by molecular orbital (MO) calculations and neural network (NN) QSAR technique.

Ključne riječi
camptothecin; ABCG2; neural network analysis; molecular orbital calculation

Hrčak ID: 12868

URI
https://hrcak.srce.hr/12868

Posjeta: 1.029 *