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Brain and serum beta-endorphin concentrations in trazodone treated rats

Radivoj Jadrić
Sabaheta Hasić
Emina Kiseljaković
Jozo Čorić
Jovan Radovanović
Mira Winterhalter-Jadrić

Puni tekst: engleski, pdf (137 KB) str. 79-84 preuzimanja: 323* citiraj
APA 6th Edition
Jadrić, R., Hasić, S., Kiseljaković, E., Čorić, J., Radovanović, J. i Winterhalter-Jadrić, M. (2007). Brain and serum beta-endorphin concentrations in trazodone treated rats. Biochemia Medica, 17 (1), 79-84. Preuzeto s https://hrcak.srce.hr/12915
MLA 8th Edition
Jadrić, Radivoj, et al. "Brain and serum beta-endorphin concentrations in trazodone treated rats." Biochemia Medica, vol. 17, br. 1, 2007, str. 79-84. https://hrcak.srce.hr/12915. Citirano 17.01.2021.
Chicago 17th Edition
Jadrić, Radivoj, Sabaheta Hasić, Emina Kiseljaković, Jozo Čorić, Jovan Radovanović i Mira Winterhalter-Jadrić. "Brain and serum beta-endorphin concentrations in trazodone treated rats." Biochemia Medica 17, br. 1 (2007): 79-84. https://hrcak.srce.hr/12915
Harvard
Jadrić, R., et al. (2007). 'Brain and serum beta-endorphin concentrations in trazodone treated rats', Biochemia Medica, 17(1), str. 79-84. Preuzeto s: https://hrcak.srce.hr/12915 (Datum pristupa: 17.01.2021.)
Vancouver
Jadrić R, Hasić S, Kiseljaković E, Čorić J, Radovanović J, Winterhalter-Jadrić M. Brain and serum beta-endorphin concentrations in trazodone treated rats. Biochemia Medica [Internet]. 2007 [pristupljeno 17.01.2021.];17(1):79-84. Dostupno na: https://hrcak.srce.hr/12915
IEEE
R. Jadrić, S. Hasić, E. Kiseljaković, J. Čorić, J. Radovanović i M. Winterhalter-Jadrić, "Brain and serum beta-endorphin concentrations in trazodone treated rats", Biochemia Medica, vol.17, br. 1, str. 79-84, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/12915. [Citirano: 17.01.2021.]
Puni tekst: hrvatski, pdf (137 KB) str. 79-84 preuzimanja: 260* citiraj
APA 6th Edition
Jadrić, R., Hasić, S., Kiseljaković, E., Čorić, J., Radovanović, J. i Winterhalter-Jadrić, M. (2007). Koncentracije beta-endorfina u serumu i mozgu kod štakora liječenih trazodonom. Biochemia Medica, 17 (1), 79-84. Preuzeto s https://hrcak.srce.hr/12915
MLA 8th Edition
Jadrić, Radivoj, et al. "Koncentracije beta-endorfina u serumu i mozgu kod štakora liječenih trazodonom." Biochemia Medica, vol. 17, br. 1, 2007, str. 79-84. https://hrcak.srce.hr/12915. Citirano 17.01.2021.
Chicago 17th Edition
Jadrić, Radivoj, Sabaheta Hasić, Emina Kiseljaković, Jozo Čorić, Jovan Radovanović i Mira Winterhalter-Jadrić. "Koncentracije beta-endorfina u serumu i mozgu kod štakora liječenih trazodonom." Biochemia Medica 17, br. 1 (2007): 79-84. https://hrcak.srce.hr/12915
Harvard
Jadrić, R., et al. (2007). 'Koncentracije beta-endorfina u serumu i mozgu kod štakora liječenih trazodonom', Biochemia Medica, 17(1), str. 79-84. Preuzeto s: https://hrcak.srce.hr/12915 (Datum pristupa: 17.01.2021.)
Vancouver
Jadrić R, Hasić S, Kiseljaković E, Čorić J, Radovanović J, Winterhalter-Jadrić M. Koncentracije beta-endorfina u serumu i mozgu kod štakora liječenih trazodonom. Biochemia Medica [Internet]. 2007 [pristupljeno 17.01.2021.];17(1):79-84. Dostupno na: https://hrcak.srce.hr/12915
IEEE
R. Jadrić, S. Hasić, E. Kiseljaković, J. Čorić, J. Radovanović i M. Winterhalter-Jadrić, "Koncentracije beta-endorfina u serumu i mozgu kod štakora liječenih trazodonom", Biochemia Medica, vol.17, br. 1, str. 79-84, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/12915. [Citirano: 17.01.2021.]

Sažetak
Introduction: Beta (β) endorphins have been detected in the hypothalamus and pituitary, and in a small amount in other organs. The aim of our study was to establish the possible influence of psychotropic drugs on serum and brain β-endorphins in rats as experimental model.
Material and methods: The study was performed on albino Wistar rats (200-250 g body weight), using the antidepressant trazodone. RIA technique was employed for quantification of serum and brain β-endorphins.
Results: Serum β-endorphins measured on day 1 of trazodone application were significantly higher (72.31 ± 1.86 pg/mL; x± SEM) compared to baseline values (45.83 ± 3.77 pg/mL; P = 0.001). However, trazodone produced significantly lower β-endorphin concentrations on day 9 of treatment (33.4 ±1.91 pg/mL) compared to the values measured on day 1 of trazodone administration (P = 0.001). Endorphin concentrations recorded on day 28 (38.62 ± 1.42 pg/mL) were higher compared to those measured on day 9 (P = 0.439). Data on brain β-endorphin concentration showed a significant decrease on day 1 of trazodone administration (431.03 ± 11.57 pg/g) compared to data obtained from control rat brains (873.5 ± 18.32 pg/g; P = 0.001). Statistical significance was also recorded by comparison of the lower data obtained on day 9 of treatment (433.65 ± 14.67 pg/g) and those observed in the control group (P = 0.001). In trazodone treated rats, brain β-endorphins were significantly higher on day 28 (929 ± 18.13 pg/g) compared with the levels measured on day 1 and day 9 of treatment (P = 0.001 both), showing slightly higher values than in control rats, yet without statistical significance (P = 0.137).
Conclusion: Chronic trazodone treatment causes an increase in the brain β-endorphin synthesis, while acute drug administration results only in a rapid release of β-endorphins into the circulation.

Ključne riječi
β-endorphins; rat; psychoactive drugs; trazodone

Hrčak ID: 12915

URI
https://hrcak.srce.hr/12915

[hrvatski]

Posjeta: 1.156 *