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Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer

INES MRAKOVČIĆ-ŠUTIĆ
VLATKA SOTOŠEK TOKMADŽIĆ

Puni tekst: engleski, pdf (2 MB) str. 409-415 preuzimanja: 314* citiraj
APA 6th Edition
MRAKOVČIĆ-ŠUTIĆ, I. i SOTOŠEK TOKMADŽIĆ, V. (2014). Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer. Periodicum biologorum, 116 (4), 409-415. Preuzeto s https://hrcak.srce.hr/138307
MLA 8th Edition
MRAKOVČIĆ-ŠUTIĆ, INES i VLATKA SOTOŠEK TOKMADŽIĆ. "Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer." Periodicum biologorum, vol. 116, br. 4, 2014, str. 409-415. https://hrcak.srce.hr/138307. Citirano 13.08.2020.
Chicago 17th Edition
MRAKOVČIĆ-ŠUTIĆ, INES i VLATKA SOTOŠEK TOKMADŽIĆ. "Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer." Periodicum biologorum 116, br. 4 (2014): 409-415. https://hrcak.srce.hr/138307
Harvard
MRAKOVČIĆ-ŠUTIĆ, I., i SOTOŠEK TOKMADŽIĆ, V. (2014). 'Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer', Periodicum biologorum, 116(4), str. 409-415. Preuzeto s: https://hrcak.srce.hr/138307 (Datum pristupa: 13.08.2020.)
Vancouver
MRAKOVČIĆ-ŠUTIĆ I, SOTOŠEK TOKMADŽIĆ V. Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer. Periodicum biologorum [Internet]. 2014 [pristupljeno 13.08.2020.];116(4):409-415. Dostupno na: https://hrcak.srce.hr/138307
IEEE
I. MRAKOVČIĆ-ŠUTIĆ i V. SOTOŠEK TOKMADŽIĆ, "Cross talk between NKT and regulatory T cells (Tregs) in prostatic tissue of patients with benign prostatic hyperplasia and prostate cancer", Periodicum biologorum, vol.116, br. 4, str. 409-415, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/138307. [Citirano: 13.08.2020.]

Sažetak
Background and Purpose: Regulatory T cells (Tregs) and NKT cells
are two subpopulations of T lymphocytes that independently regulate innate and adaptive immunity, but there is some evidence for cross-talk between Tregs and NKT cells, which allow a new immunoregulatory networks. Activated NKT cells may modulate quantitatively and qualitatively the function of Tregs through IL-2-dependent mechanisms, while Tregs can suppress the proliferation, cytokine release and cytotoxic activity of NKT cells by cell-contact-dependent mechanisms. Tregs may control tumor expansion
at the priming, as well as the effector’s phase of T immune responses.
Tumor cells provide antigenic stimulation of T cells and interact with the tumor-infiltrated innate immune cells secreting cytokines that are crucial for T-cell differentiation.

Patients and Methods: In this study we examined the prostate tissue
infiltrating lymphocytes of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) by flow cytometric technique (FACSCalibur) for determine the number of T, B, NK, NKT and Tregs and investigate the local regulatory immunosurveillance which allows the tumor’s immuneescape.

Results: Our results have shown the statistically significantly elevated
number of Tregs in prostatic tissue and slightly diminished percentage of NKT cells in prostate cancer patients in comparison to patients with benign prostatic hyperplasia.

Conclusion: Although the exact mechanism is still unknown, increased
infiltration of prostate tissue with T regulatory cells seems that stimulate the tumor to secrete factors (chemokines) that attract these cells in the tissue of the prostate where they achieve their anti-tumor effect and thus may contribute the tumor progression

Ključne riječi
benign prostatic hyperplasia; innate immunity, malignancies; NKT cells; prostate cancer; regulatory T cells

Hrčak ID: 138307

URI
https://hrcak.srce.hr/138307

Posjeta: 496 *