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https://doi.org/10.2478/v10007-007-0024-6

Swelling behavior and release properties of pH-sensitive hydrogels based on methacrylic derivatives

TAHAR BARTIL
MAHMOUD BOUNEKHEL
CALBERG CEDRIC
ROBERT JEROME

Puni tekst: engleski, pdf (173 KB) str. 301-314 preuzimanja: 3.940* citiraj
APA 6th Edition
BARTIL, T., BOUNEKHEL, M., CEDRIC, C. i JEROME, R. (2007). Swelling behavior and release properties of pH-sensitive hydrogels based on methacrylic derivatives. Acta Pharmaceutica, 57 (3), 301-314. https://doi.org/10.2478/v10007-007-0024-6
MLA 8th Edition
BARTIL, TAHAR, et al. "Swelling behavior and release properties of pH-sensitive hydrogels based on methacrylic derivatives." Acta Pharmaceutica, vol. 57, br. 3, 2007, str. 301-314. https://doi.org/10.2478/v10007-007-0024-6. Citirano 27.06.2019.
Chicago 17th Edition
BARTIL, TAHAR, MAHMOUD BOUNEKHEL, CALBERG CEDRIC i ROBERT JEROME. "Swelling behavior and release properties of pH-sensitive hydrogels based on methacrylic derivatives." Acta Pharmaceutica 57, br. 3 (2007): 301-314. https://doi.org/10.2478/v10007-007-0024-6
Harvard
BARTIL, T., et al. (2007). 'Swelling behavior and release properties of pH-sensitive hydrogels based on methacrylic derivatives', Acta Pharmaceutica, 57(3), str. 301-314. doi: https://doi.org/10.2478/v10007-007-0024-6
Vancouver
BARTIL T, BOUNEKHEL M, CEDRIC C, JEROME R. Swelling behavior and release properties of pH-sensitive hydrogels based on methacrylic derivatives. Acta Pharm. [Internet]. 2007 [pristupljeno 27.06.2019.];57(3):301-314. doi: https://doi.org/10.2478/v10007-007-0024-6
IEEE
T. BARTIL, M. BOUNEKHEL, C. CEDRIC i R. JEROME, "Swelling behavior and release properties of pH-sensitive hydrogels based on methacrylic derivatives", Acta Pharmaceutica, vol.57, br. 3, str. 301-314, 2007. [Online]. doi: https://doi.org/10.2478/v10007-007-0024-6

Sažetak
The purpose of this study is to develop novel intestinal-specific drug delivery systems with pH sensitive swelling and drug release properties. Methacrylic-type polymeric prodrugs were synthesized by free radical copolymerization of methacrylic acid, poly(ethyleneglycol monomethyl ether methacrylate) and a methacrylic derivative of N-(4-hydroxyphenyl)-2-(4-methoxyphenyl) acetamide in the presence of ethylene glycol dimethacrylate as crosslinking agent. The effect of copolymer composition on the swelling behavior and hydrolytic degradation were studied in simulated gastric (SGF, pH 1.2) and intestinal fluids (SIF, pH 7.0). The dynamic swelling behavior of these hydrogels was investigated to determine the mechanism of water transport through these hydrogels. The mechanism of water transport through the gels was significantly affected by the pH of the swelling medium and became more relaxation-controlled in a swelling medium of pH 7.0. The swelling and hydrolytic behaviors of hydrogels were dependent on the content of methacrylic acid (MAA) groups and caused a decrease and increase in gel swelling in SGF and SIF, respectively. Drug release studies showed that the increasing content of MAA acid in the copolymer enhances hydrolysis in SIF. These results suggest that pH-sensitive systems could be useful for preparation of a muccoadhesive system and controlled release of N-(4-hydroxyphenyl)-2-(4-methoxyphenyl) acetamide.

Ključne riječi
pH-sensitive hydrogels; swelling; controlled release; poly(ethylene glycol); poly(methacrylic acid)

Hrčak ID: 13578

URI
https://hrcak.srce.hr/13578

[hrvatski]

Posjeta: 4.418 *