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https://doi.org/10.5562/cca2595

9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation

Elma Veljović ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Selma Špirtović-Halilović ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Samija Muratović ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Lidija Valek Žulj ; Department of Electrochemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia
Sunčica Roca ; NMR Centre, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia
Snežana Trifunović ; Faculty of Chemistry, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia
Amar Osmanović ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Davorka Završnik ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina

Puni tekst: engleski, pdf (2 MB) str. 121-127 preuzimanja: 785* citiraj
APA 6th Edition
Veljović, E., Špirtović-Halilović, S., Muratović, S., Valek Žulj, L., Roca, S., Trifunović, S., ... Završnik, D. (2015). 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation. Croatica Chemica Acta, 88 (2), 121-127. https://doi.org/10.5562/cca2595
MLA 8th Edition
Veljović, Elma, et al. "9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation." Croatica Chemica Acta, vol. 88, br. 2, 2015, str. 121-127. https://doi.org/10.5562/cca2595. Citirano 07.04.2020.
Chicago 17th Edition
Veljović, Elma, Selma Špirtović-Halilović, Samija Muratović, Lidija Valek Žulj, Sunčica Roca, Snežana Trifunović, Amar Osmanović i Davorka Završnik. "9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation." Croatica Chemica Acta 88, br. 2 (2015): 121-127. https://doi.org/10.5562/cca2595
Harvard
Veljović, E., et al. (2015). '9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation', Croatica Chemica Acta, 88(2), str. 121-127. https://doi.org/10.5562/cca2595
Vancouver
Veljović E, Špirtović-Halilović S, Muratović S, Valek Žulj L, Roca S, Trifunović S i sur. 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation. Croatica Chemica Acta [Internet]. 2015 [pristupljeno 07.04.2020.];88(2):121-127. https://doi.org/10.5562/cca2595
IEEE
E. Veljović, et al., "9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation", Croatica Chemica Acta, vol.88, br. 2, str. 121-127, 2015. [Online]. https://doi.org/10.5562/cca2595

Sažetak
Oxidative stress is directly related to several diseases and symptoms, where antioxidant compounds, such as xanthenes, may become important in prevention and/or treatmant. Ten biologically active 9-aryl substituted 2,6,7-trihydroxyxanthen-3-one derivatives were synthesized using reliable one-pot synthesis and their structures were confirmed by IR, 1H and 13C NMR spectroscopy and mass spectrometry. Some of the synthesized compounds were scanned for their antioxidant potency using electrochemical method cyclic voltammetry of immobilized microparticles. Substitution of hydrogen at the phenyl ring of 2,6,7-trihydroxy-9-phenylxanthen-3-one with an electron-donating group affected the reducing power of the compounds by lowering the biological oxidation potential. These results signify the importance of xanthen-3-one derivatives as antioxidant agents and their further biological evaluation.

Ključne riječi
xanthen-3-one derivatives; antioxidant potency; cyclic voltammetry

Hrčak ID: 141983

URI
https://hrcak.srce.hr/141983

Posjeta: 1.167 *