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Association Between Single Nucleotide Polymorphisms of the Interleukin-4 Gene and Atopic Dermatitis

Mohammad Gharagozlou
Nasrin Behniafard
Ali Akbar Amirargar
Sima Hosseinverdi
Soheila Sotoudeh
Elham Farhadi
Mojdeh Khaledi
Zahra Aryan
Zahra Gholizadeh Moghaddam
Maryam Mahmoudi
Asghar Aghamohammadi
Nima Rezaei

Puni tekst: engleski, PDF (136 KB) str. 96-96 preuzimanja: 263* citiraj
APA 6th Edition
Gharagozlou, M., Behniafard, N., Akbar Amirargar, A., Hosseinverdi, S., Sotoudeh, S., Farhadi, E., ... Rezaei, N. (2015). Association Between Single Nucleotide Polymorphisms of the Interleukin-4 Gene and Atopic Dermatitis. Acta Dermatovenerologica Croatica, 23 (2), 96-96. Preuzeto s https://hrcak.srce.hr/142137
MLA 8th Edition
Gharagozlou, Mohammad, et al. "Association Between Single Nucleotide Polymorphisms of the Interleukin-4 Gene and Atopic Dermatitis." Acta Dermatovenerologica Croatica, vol. 23, br. 2, 2015, str. 96-96. https://hrcak.srce.hr/142137. Citirano 22.10.2021.
Chicago 17th Edition
Gharagozlou, Mohammad, Nasrin Behniafard, Ali Akbar Amirargar, Sima Hosseinverdi, Soheila Sotoudeh, Elham Farhadi, Mojdeh Khaledi, et al. "Association Between Single Nucleotide Polymorphisms of the Interleukin-4 Gene and Atopic Dermatitis." Acta Dermatovenerologica Croatica 23, br. 2 (2015): 96-96. https://hrcak.srce.hr/142137
Harvard
Gharagozlou, M., et al. (2015). 'Association Between Single Nucleotide Polymorphisms of the Interleukin-4 Gene and Atopic Dermatitis', Acta Dermatovenerologica Croatica, 23(2), str. 96-96. Preuzeto s: https://hrcak.srce.hr/142137 (Datum pristupa: 22.10.2021.)
Vancouver
Gharagozlou M, Behniafard N, Akbar Amirargar A, Hosseinverdi S, Sotoudeh S, Farhadi E i sur. Association Between Single Nucleotide Polymorphisms of the Interleukin-4 Gene and Atopic Dermatitis. Acta Dermatovenerol Croat. [Internet]. 2015 [pristupljeno 22.10.2021.];23(2):96-96. Dostupno na: https://hrcak.srce.hr/142137
IEEE
M. Gharagozlou, et al., "Association Between Single Nucleotide Polymorphisms of the Interleukin-4 Gene and Atopic Dermatitis", Acta Dermatovenerologica Croatica, vol.23, br. 2, str. 96-96, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/142137. [Citirano: 22.10.2021.]

Sažetak

ABSTRACT Atopic dermatitis (AD) is an inflammatory skin disease in which both genetic and environmental factors seem to be involved. Several studies investigated the association of certain genetic factors with AD in different ethnic groups, but conflicting data were obtained. This study was performed to check the possible association between single nucleotide polymorphisms (SNPs) of interleukin 4 (IL-4) and the IL-4 receptor α chain (IL-4Rα) and AD in a group of Iranian patients. The allele and genotype frequencies of genes encoding for IL-4 and IL-4Rα were investigated in 89 patients with AD in comparison with 139 healthy controls, using methods based on polymerase chain reaction sequence-specific primers. The most frequent alleles of IL-4 in patients were T at -1098 (P<0.001, odds ratio (OR)=2.35), C at -590 (P<0.001, OR=4.84) and C at -33 (P=0.002, OR=2.08). The most frequent genotypes of IL-4 in patients were TT, CC, and CC at positions -1098 (P<0.001, OR=3.59), -590 (P<0.001, OR=31.25) and -33 (P<0.001, OR=3.46), respectively. We found a significant lower frequency of GT at -1098 GT, TC at -590, and TC at -33 in patients. There were no statistically significant differences in the frequency of alleles and genotypes of IL-4Rα gene at position +1902. A strong positive association was seen between TCC haplotype and AD (68% in patients vs. 23.4% in controls, P<0.001, OR=8.91). We detected a significantly lower frequency of TTC, GCC, and TTT haplotypes (P<0.001, OR=0.02, P<0.001, OR=0.40, P<0.001, OR=0.39, respectively) in patients compared to controls. A significant association between the polymorphisms of the IL-4 gene promoter at positions -1098, -590, and -33 and AD was detected in the Iranian population.

 

Key words: atopic dermatitis; polymorphism, single nucleotide; interleukin-4 gene

Hrčak ID: 142137

URI
https://hrcak.srce.hr/142137

Posjeta: 533 *