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Prevalence and Antifungal Susceptibility Patterns of Dermatophytes Isolated from Patients with Neoplastic Diseases: A Case Control Study

Marius Irimie ; Transilvania University Brasov
Alexandru Oanta ; Transilvania University of Brasov
Claudia Alexandrina Irimie ; Transilvania University of Brasov
Dan Ioan Minea ; Transilvania University Brasov

Puni tekst: engleski, PDF (119 KB) str. 108-108 preuzimanja: 241* citiraj
APA 6th Edition
Irimie, M., Oanta, A., Alexandrina Irimie, C. i Ioan Minea, D. (2015). Prevalence and Antifungal Susceptibility Patterns of Dermatophytes Isolated from Patients with Neoplastic Diseases: A Case Control Study. Acta Dermatovenerologica Croatica, 23 (2), 108-108. Preuzeto s https://hrcak.srce.hr/142139
MLA 8th Edition
Irimie, Marius, et al. "Prevalence and Antifungal Susceptibility Patterns of Dermatophytes Isolated from Patients with Neoplastic Diseases: A Case Control Study." Acta Dermatovenerologica Croatica, vol. 23, br. 2, 2015, str. 108-108. https://hrcak.srce.hr/142139. Citirano 26.10.2021.
Chicago 17th Edition
Irimie, Marius, Alexandru Oanta, Claudia Alexandrina Irimie i Dan Ioan Minea. "Prevalence and Antifungal Susceptibility Patterns of Dermatophytes Isolated from Patients with Neoplastic Diseases: A Case Control Study." Acta Dermatovenerologica Croatica 23, br. 2 (2015): 108-108. https://hrcak.srce.hr/142139
Harvard
Irimie, M., et al. (2015). 'Prevalence and Antifungal Susceptibility Patterns of Dermatophytes Isolated from Patients with Neoplastic Diseases: A Case Control Study', Acta Dermatovenerologica Croatica, 23(2), str. 108-108. Preuzeto s: https://hrcak.srce.hr/142139 (Datum pristupa: 26.10.2021.)
Vancouver
Irimie M, Oanta A, Alexandrina Irimie C, Ioan Minea D. Prevalence and Antifungal Susceptibility Patterns of Dermatophytes Isolated from Patients with Neoplastic Diseases: A Case Control Study. Acta Dermatovenerol Croat. [Internet]. 2015 [pristupljeno 26.10.2021.];23(2):108-108. Dostupno na: https://hrcak.srce.hr/142139
IEEE
M. Irimie, A. Oanta, C. Alexandrina Irimie i D. Ioan Minea, "Prevalence and Antifungal Susceptibility Patterns of Dermatophytes Isolated from Patients with Neoplastic Diseases: A Case Control Study", Acta Dermatovenerologica Croatica, vol.23, br. 2, str. 108-108, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/142139. [Citirano: 26.10.2021.]

Sažetak

ABSTRACT Patients with neoplasia who are severely immunocompromised have a higher risk of fungal infections. There are limited data in the literature regarding the frequency of dermatophyte infections and efficacy of antifungals in patients with malignancies.

Objective was assessment of the incidence of dermatophyte infections and antifungal susceptibility, determination of dermatophyte species isolated from patients with neoplastic diseases. 138 patients diagnosed with various malignancies and 160 immunocompetent patients who were referred to the Department of Dermatology in Brasov, Romania, for suspicion of dermatophyte infections were included in the study. Nail clippings or skin scrapings were examined by direct microscopy and cultures in Sabouraud agar medium. Susceptibility tests for antifungals were conducted in vitro using a method of broth microdilution.  Infections with dermatophytes were identified in 30.4% of patients with neoplastic diseases and in 29.37% in the control group. There was a significantly higher frequency of dermatophyte infections in patients with hematologic malignancies (52%) compared to those with solid cancers (25.66%) (P=0.01). The clinical aspects of dermatophyte infections in patients with neoplastic diseases were not different from those of patients without cancer; though in some cases the infections were more extensive. There were no statistically significant differences between mean values of minimum inhibitory concentration of antifungals compared with controls. Terbinafine had the highest antidermatophyte activity for all tested dermatophyte species isolated from patients with neoplastic diseases.

There were no differences in frequency of dermatophyte infections and antifungal susceptibility to dermatophytes between patients with neoplastic diseases and immunocompetent patients.

 

KEY WORDS: dermatophyte; neoplasia; antifungals; in vitro susceptibility

Ključne riječi
dermatophyte; neoplasia; antifungals; in vitro susceptibility

Hrčak ID: 142139

URI
https://hrcak.srce.hr/142139

Posjeta: 437 *