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Professional paper

Prescribing nonsteroidal anti-rheumatics in family medicine

Tamara Kovačić ; Dom zdravlja Zagreb Zapad, Zagreb
Ivančica Peček ; Dom zdravlja Zagreb Zapad, Zagreb
Ksenija Kranjčević ; Dom zdravlja Zagreb Zapad, Zagreb
Stanislava Stojanović Špehar ; Specijalistička ordinacija obiteljske medicine Stanislava Stojanović-Špehar,, Zagreb

Fulltext: croatian, pdf (388 KB) pages 49-59 downloads: 307* cite
APA 6th Edition
Kovačić, T., Peček, I., Kranjčević, K. & Stojanović Špehar, S. (2015). Propisivanje nesteroidnih antireumatika u obiteljskoj medicini. Medica Jadertina, 45 (1-2), 49-59. Retrieved from
MLA 8th Edition
Kovačić, Tamara, et al. "Propisivanje nesteroidnih antireumatika u obiteljskoj medicini." Medica Jadertina, vol. 45, no. 1-2, 2015, pp. 49-59. Accessed 12 Aug. 2020.
Chicago 17th Edition
Kovačić, Tamara, Ivančica Peček, Ksenija Kranjčević and Stanislava Stojanović Špehar. "Propisivanje nesteroidnih antireumatika u obiteljskoj medicini." Medica Jadertina 45, no. 1-2 (2015): 49-59.
Kovačić, T., et al. (2015). 'Propisivanje nesteroidnih antireumatika u obiteljskoj medicini', Medica Jadertina, 45(1-2), pp. 49-59. Available at: (Accessed 12 August 2020)
Kovačić T, Peček I, Kranjčević K, Stojanović Špehar S. Propisivanje nesteroidnih antireumatika u obiteljskoj medicini. Medica Jadertina [Internet]. 2015 [cited 2020 August 12];45(1-2):49-59. Available from:
T. Kovačić, I. Peček, K. Kranjčević and S. Stojanović Špehar, "Propisivanje nesteroidnih antireumatika u obiteljskoj medicini", Medica Jadertina, vol.45, no. 1-2, pp. 49-59, 2015. [Online]. Available: [Accessed: 12 August 2020]

According to HALMED (Croatian agency for medical products and medical devices) the consumption of NSAID (M01) occupied eighth place with 42.43 DDD/1000 inhabitants/day in 2012.
Objective: To investigate the frequency of NSAIDs in GP offices regarding: participation in drug expenditure, indications, duration of therapy, unwanted comorbid diseases and drug interactions.
Patients and methods: Retrospective longitudinal study of a sample of 5,716 patients from three GP offices was carried out in a one-year period (1.1.2011-31.12.2011). The sample included 1,194 patients with prescribed NSAID. A questionnaire designed for this investigation included questions about patients' demographic and social characteristics, clinical information and the pattern of NSAID prescription (subgroup and DDD). Data were taken from computerized medical records in the information system
Results: NSAIDs were prescribed to 21% of patients. Musculoskeletal diseases (67.8 %) were the most common reason to prescribe NSAID. The average duration of the therapy was 49.2 DDD (SD 62.0). The most commonly prescribed NSAID was ibuprofen (31.6%). Two or more NSAIDs were prescribed to 14 % of respondents. The most common unwanted comorbidities were cardiovascular (38.4 %), and then gastrointestinal (17%) followed by renal diseases (1%). The most common unwanted drug interaction was with diuretics (34.1%). NSAIDs participated with about 2 % in total drug expenditure in GP offices.
Conclusion: NSAIDs were prescribed to every fifth patient too often and too long. More than a half of the patients had unwanted comorbid diagnoses. The recommendation for further investigation is to investigate the outcome measures of prescribed NSAID among patients with unwanted diseases and drug interactions and to calculate real expenditure which generated NSAID prescription.

NSAID; comorbidity; drug interacion; drug expenditure, family medicine

Hrčak ID: 143635



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