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Metal exposure studies: role of toxicology and epidemiology in public health policy

Marko Šarić ; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Martina Piasek ; Institute for Medical Research and Occupational Health, Zagreb, Croatia

Puni tekst: engleski, pdf (7 MB) str. 307-316 preuzimanja: 173* citiraj
APA 6th Edition
Šarić, M. i Piasek, M. (1997). Metal exposure studies: role of toxicology and epidemiology in public health policy. Arhiv za higijenu rada i toksikologiju, 48 (3), 307-316. Preuzeto s https://hrcak.srce.hr/144361
MLA 8th Edition
Šarić, Marko i Martina Piasek. "Metal exposure studies: role of toxicology and epidemiology in public health policy." Arhiv za higijenu rada i toksikologiju, vol. 48, br. 3, 1997, str. 307-316. https://hrcak.srce.hr/144361. Citirano 27.02.2021.
Chicago 17th Edition
Šarić, Marko i Martina Piasek. "Metal exposure studies: role of toxicology and epidemiology in public health policy." Arhiv za higijenu rada i toksikologiju 48, br. 3 (1997): 307-316. https://hrcak.srce.hr/144361
Harvard
Šarić, M., i Piasek, M. (1997). 'Metal exposure studies: role of toxicology and epidemiology in public health policy', Arhiv za higijenu rada i toksikologiju, 48(3), str. 307-316. Preuzeto s: https://hrcak.srce.hr/144361 (Datum pristupa: 27.02.2021.)
Vancouver
Šarić M, Piasek M. Metal exposure studies: role of toxicology and epidemiology in public health policy. Arh Hig Rada Toksikol. [Internet]. 1997 [pristupljeno 27.02.2021.];48(3):307-316. Dostupno na: https://hrcak.srce.hr/144361
IEEE
M. Šarić i M. Piasek, "Metal exposure studies: role of toxicology and epidemiology in public health policy", Arhiv za higijenu rada i toksikologiju, vol.48, br. 3, str. 307-316, 1997. [Online]. Dostupno na: https://hrcak.srce.hr/144361. [Citirano: 27.02.2021.]

Sažetak
Following the idea of interrelated role of epidemiology and toxicology in risk assessment and dose response evaluation, this paper presents certain experiences from ihe authors' studies of health effects of environmental exposure to lead and manganese. Epidemiologic observations of adverse effects on female reproductive integrity in a lead smeltery area agree with the experimental data animal studies show that the adverse reproductive effects in females are time and dose-related, and reversible after exposure has ceased. Field studies show that effects of manganese on the respiratory system in a polluted region are dose, age and season-related. Cytotoxic effects of manganese, including the inhibitory effect on alveolar macrophages described in in vitro studies on mammalian cells confirm the epidemiologic observations. Authors conclude that in the process of risk assessment, toxicology and epidemiology have to act together. Available human data should be combined with experimental findings and data on the mechanism of toxic action.

Ključne riječi
cytotoxic effects; lead exposure; manganese exposure; reproductive effects; respiratory effects

Hrčak ID: 144361

URI
https://hrcak.srce.hr/144361

[hrvatski]

Posjeta: 352 *