Veterinarski arhiv, Vol. 85 No. 4, 2015.
Izvorni znanstveni članak
The effects of caffeic acid phenethyl ester (CAPE) treatment on rheumatologic parameters and iron metabolism in diabetic rats.
Ismail Aytekin
; Department of Internal Medicine, Faculty of Veterinary Medicine, Balıkesir University, Balıkesir, Turkey
Alparslan K. Devrim
; Department of Biochemistry, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, Turkey
Aliye S. Ozturk
; Department of Internal Medicine, Faculty of Veterinary Medicine, Mustafa Kemal University, Hatay, Turkey
Hasan Aksit
; Department of Biochemistry, Faculty of Veterinary Medicine, Balıkesir University, Balıkesir, Turkey
Nuri Mamak
; Department of Internal Medicine, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, Turkey
Sahver E. Hismiogullari
; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Balıkesir University, Balıkesir, Turkey
Sažetak
Diabetology and rheumatology have much in common, including many biochemical features. Diabetic cases suffer excessively from common musculoskeletal conditions. The present study aimed to explore the association between the caffeic acid phenethyl ester (CAPE) treatment and the standard parameters of diabetic and rheumatologic controls. Serum anti-streptolysin-O (ASO), C-reactive protein (CRP), rheumatoid factor (RF) titers and glucose (GLU), cholesterol (CHOL), triglyceride (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), sodium (Na), potassium (K), chloride (Cl), calcium (Ca), phosphorus (P), uric acid (UA), iron (Fe), iron-binding capacity (IBC), total iron-binding capacity (TIBC) and superoxide dismutase (SOD) levels were measured in 22 female Wistar-Albino rats. The animals were divided into three groups: group 1: non-diabetic rats as control; group 2: streptozotocin (STZ)-induced, untreated diabetic rats; and group 3: STZ-induced, CAPE-treated diabetic rats. Levels of GLU were increased in group 2. ASO values were decreased in group 3. TG and VLDL levels were increased in group 3 compared with the group 1. Higher UA levels were detected in group 3 compared with group 2. The levels of Fe and TIBC were decreased in group 3. The results of the present study indicate the reducing effect of CAPE on the serum levels of diabetic and rheumatologic parameters in diabetic rats.
Ključne riječi
caffeic acid phenethyl ester (CAPE); diabetes; iron; rat; rheumatologic parameters
Hrčak ID:
145366
URI
Datum izdavanja:
2.9.2015.
Posjeta: 1.449 *