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Acta Pharmaceutica, Vol. 66 No. 1, 2016.

Izvorni znanstveni članak
https://doi.org/10.1515/acph-2016-0005

Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents

RAFAT M. MOHAREB ; Department of Chemistry, Faculty of Science, Cairo University, Giza, A. R. Egypt
AMIRA. E. M. ABDALLAH ; Department of Chemistry, Faculty of Science, Helwan University, AinHelwan, Cairo A. R. Egypt
MAHER H. E. HELAL ; Department of Chemistry, Faculty of Science, Helwan University, AinHelwan, Cairo A. R. Egypt
SOMIYA M. H. SHALOOF ; Department of Chemistry, Faculty of Science, Western MountainUniversity, Alzintan, Libya

Puni tekst: engleski, pdf (416 KB) str. 53-68 preuzimanja: 521* citiraj
APA 6th Edition
MOHAREB, R.M., ABDALLAH, A.E.M., HELAL, M.H.E. i SHALOOF, S.M.H. (2016). Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents. Acta Pharmaceutica, 66 (1), 53-68. https://doi.org/10.1515/acph-2016-0005
MLA 8th Edition
MOHAREB, RAFAT M., et al. "Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents." Acta Pharmaceutica, vol. 66, br. 1, 2016, str. 53-68. https://doi.org/10.1515/acph-2016-0005. Citirano 22.05.2019.
Chicago 17th Edition
MOHAREB, RAFAT M., AMIRA. E. M. ABDALLAH, MAHER H. E. HELAL i SOMIYA M. H. SHALOOF. "Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents." Acta Pharmaceutica 66, br. 1 (2016): 53-68. https://doi.org/10.1515/acph-2016-0005
Harvard
MOHAREB, R.M., et al. (2016). 'Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents', Acta Pharmaceutica, 66(1), str. 53-68. doi: https://doi.org/10.1515/acph-2016-0005
Vancouver
MOHAREB RM, ABDALLAH AEM, HELAL MHE, SHALOOF SMH. Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents. Acta Pharm. [Internet]. 2016 [pristupljeno 22.05.2019.];66(1):53-68. doi: https://doi.org/10.1515/acph-2016-0005
IEEE
R.M. MOHAREB, A.E.M. ABDALLAH, M.H.E. HELAL i S.M.H. SHALOOF, "Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents", Acta Pharmaceutica, vol.66, br. 1, str. 53-68, 2016. [Online]. doi: https://doi.org/10.1515/acph-2016-0005

Sažetak
Attempting to produce cyclized systems with potential anti-proliferative activity, a series of novel thiophene and benzothiophene derivatives were designed and synthesized. The reactivity of the latter derivatives towards different chemical reagents was studied. Twenty-one compounds were evaluated as anti-cancer agents. The results showed that ethyl 5-amino-3-(4-chlorostyryl)-4-cyanothiophene-2-carboxylate (5b) ethyl 5-amino-4-((4-methoxyphenyl)carbonyl)-3-methylhiophene-2-carboxylate (8c) and 5-3-(ethoxy-3-oxopropanamido)-3-methyl-4-(phenylcarbamoyl)thiophene-2-carboxylate (9) were the most active compounds towards three tumor cell lines – MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer) and a normal fibroblast human cell line (WI-38), compared to the anti-proliferative effects of the reference control doxorubicin.

Ključne riječi
thiophene; benzothiophene; cytotoxic agents

Hrčak ID: 146014

URI
https://hrcak.srce.hr/146014

Posjeta: 706 *