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Original scientific paper
https://doi.org/10.1515(acph-2016-0014

Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus

BAHAA G. M. YOUSSIF ; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt; Pharmaceutical Chemistry Department, College of Pharmacy, Al Jouf University, AlJouf, Sakaka-2014, Kingdom of Saudi Arabia
YASEEN A. M. MOHAMED ; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University,Assiut Branch, Egypt
MOHAMMED T. A. SALIM ; Microbiology and Immunology Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Egypt
FUYUHIKO INAGAKI ; Division of Pharmaceutical Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
CHISATO MUKAI ; Division of Pharmaceutical Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
HAJJAJ H. M. ABDU-ALLAH   ORCID icon orcid.org/0000-0002-4474-9086 ; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt

Fulltext: english, pdf (596 KB) pages 219-231 downloads: 656* cite
APA 6th Edition
YOUSSIF, B.G.M., MOHAMED, Y.A.M., SALIM, M.T.A., INAGAKI, F., MUKAI, C. & ABDU-ALLAH, H.H.M. (2016). Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus. Acta Pharmaceutica, 66 (2), 219-231. https://doi.org/10.1515(acph-2016-0014
MLA 8th Edition
YOUSSIF, BAHAA G. M., et al. "Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus." Acta Pharmaceutica, vol. 66, no. 2, 2016, pp. 219-231. https://doi.org/10.1515(acph-2016-0014. Accessed 21 Jul. 2019.
Chicago 17th Edition
YOUSSIF, BAHAA G. M., YASEEN A. M. MOHAMED, MOHAMMED T. A. SALIM, FUYUHIKO INAGAKI, CHISATO MUKAI and HAJJAJ H. M. ABDU-ALLAH. "Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus." Acta Pharmaceutica 66, no. 2 (2016): 219-231. https://doi.org/10.1515(acph-2016-0014
Harvard
YOUSSIF, B.G.M., et al. (2016). 'Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus', Acta Pharmaceutica, 66(2), pp. 219-231. https://doi.org/10.1515(acph-2016-0014
Vancouver
YOUSSIF BGM, MOHAMED YAM, SALIM MTA, INAGAKI F, MUKAI C, ABDU-ALLAH HHM. Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus. Acta Pharm. [Internet]. 2016 [cited 2019 July 21];66(2):219-231. https://doi.org/10.1515(acph-2016-0014
IEEE
B.G.M. YOUSSIF, Y.A.M. MOHAMED, M.T.A. SALIM, F. INAGAKI, C. MUKAI and H.H.M. ABDU-ALLAH, "Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus", Acta Pharmaceutica, vol.66, no. 2, pp. 219-231, 2016. [Online]. https://doi.org/10.1515(acph-2016-0014

Abstracts
New derivatives of 2-thiobenzimidazole incorporating triazole moiety were synthesized, characterized and tested in vitro for antiviral activity against hepatitis C virus (HCV) and hepatitis B virus (HBV). Their cytotoxicity was determined by the reduction in number of viable cells. All of the synthesized compounds are inactive against HBV and some showed activity against HCV. In particular, two compounds showed significant activity, 2-{4-[(1-benzoylbenzimidazol-2-ylthio)methyl]-1H-1,2,3-triazol-1-yl}-N-(p-nitrophenyl)-acetamide (13) and 2-(4-{[1-(p-chlorobenzoyl)-benzimidazol-2-ylthio)methyl]-1H-1,2,3-triazol-1-yl}-N-(p-nitrophenyl)-acetamide (17). The results give an insight into the importance of the substituent at position 2 of benzimidazole for the inhibition of HCV.

Keywords
benzimidazole; triazole; anilide; antiviral; HCV; HBV

Hrčak ID: 147488

URI
https://hrcak.srce.hr/147488

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