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Acta Pharmaceutica, Vol. 66 No. 2, 2016.

Izvorni znanstveni članak
https://doi.org/10.1515/acph-2016-0013

Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs

WUSAN WANG
HUI JI
TINGTING LI
YUANWEI JIA
HAITANG XIE

Puni tekst: engleski, pdf (605 KB) str. 279-287 preuzimanja: 247* citiraj
APA 6th Edition
WANG, W., JI, H., LI, T., JIA, Y. i XIE, H. (2016). Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs. Acta Pharmaceutica, 66 (2), 279-287. https://doi.org/10.1515/acph-2016-0013
MLA 8th Edition
WANG, WUSAN, et al. "Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs." Acta Pharmaceutica, vol. 66, br. 2, 2016, str. 279-287. https://doi.org/10.1515/acph-2016-0013. Citirano 23.02.2019.
Chicago 17th Edition
WANG, WUSAN, HUI JI, TINGTING LI, YUANWEI JIA i HAITANG XIE. "Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs." Acta Pharmaceutica 66, br. 2 (2016): 279-287. https://doi.org/10.1515/acph-2016-0013
Harvard
WANG, W., et al. (2016). 'Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs', Acta Pharmaceutica, 66(2), str. 279-287. doi: https://doi.org/10.1515/acph-2016-0013
Vancouver
WANG W, JI H, LI T, JIA Y, XIE H. Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs. Acta Pharm. [Internet]. 2016 [pristupljeno 23.02.2019.];66(2):279-287. doi: https://doi.org/10.1515/acph-2016-0013
IEEE
W. WANG, H. JI, T. LI, Y. JIA i H. XIE, "Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs", Acta Pharmaceutica, vol.66, br. 2, str. 279-287, 2016. [Online]. doi: https://doi.org/10.1515/acph-2016-0013

Sažetak
A pharmacokinetic comparison and conformational stability study of S-oxiracetam (S-ORT) and R-oxiracetam (R-ORT) in beagle dogs was used to investigate the possible mechanism of different effects of two oxiracetam enantiomers through a random crossover design. After drug administration to beagle dogs, blood samples were collected at different time points for pharmacokinetic analysis using the UPLC-ESI-MS/MS method. Parts of plasma samples were used for conformation transformation studies using a normal phase high performance liquid chromatographic (NP HPLC) method. The study showed that oxiracetam enantiomers maintained their original conformation when administered orally to beagle dogs. Concentrations of S-ORT were significantly higher than R-ORT 1.5 and 2 h after administration; the AUC0-∞ of S-ORT after oral administration tended to be higher than that of R-ORT, which showed that the different effects between S-ORT and R-ORT may be partly associated with their distinctive absorption at least.

Ključne riječi
S-oxiracetam; R-oxiracetam; conformation; pharmacokinetics; beagle dogs

Hrčak ID: 147489

URI
https://hrcak.srce.hr/147489

Posjeta: 378 *