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https://doi.org/10.1515/acph-2016-0016

Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents

MOSTAFA M. GHORAB ; Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Kingdom of Saudi Arabia
MANSOUR S. ALSAID ; Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Kingdom of Saudi Arabia
MOHAMMED S. AL-DOSARI ; Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Kingdom of Saudi Arabia
FATMA A. RAGAB ; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
ABDULLAH A. AL-MISHARI ; Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University; P.O. Box 2457, Riyadh 11451, Saudi Arabia
ABDULAZIZ N. ALMOQBIL ; Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University; P.O. Box 2457, Riyadh 11451, Saudi Arabia

Puni tekst: engleski, pdf (715 KB) str. 155-171 preuzimanja: 337* citiraj
APA 6th Edition
GHORAB, M.M., ALSAID, M.S., AL-DOSARI, M.S., RAGAB, F.A., AL-MISHARI, A.A. i ALMOQBIL, A.N. (2016). Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents. Acta Pharmaceutica, 66 (2), 155-171. https://doi.org/10.1515/acph-2016-0016
MLA 8th Edition
GHORAB, MOSTAFA M., et al. "Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents." Acta Pharmaceutica, vol. 66, br. 2, 2016, str. 155-171. https://doi.org/10.1515/acph-2016-0016. Citirano 17.06.2019.
Chicago 17th Edition
GHORAB, MOSTAFA M., MANSOUR S. ALSAID, MOHAMMED S. AL-DOSARI, FATMA A. RAGAB, ABDULLAH A. AL-MISHARI i ABDULAZIZ N. ALMOQBIL. "Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents." Acta Pharmaceutica 66, br. 2 (2016): 155-171. https://doi.org/10.1515/acph-2016-0016
Harvard
GHORAB, M.M., et al. (2016). 'Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents', Acta Pharmaceutica, 66(2), str. 155-171. doi: https://doi.org/10.1515/acph-2016-0016
Vancouver
GHORAB MM, ALSAID MS, AL-DOSARI MS, RAGAB FA, AL-MISHARI AA, ALMOQBIL AN. Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents. Acta Pharm. [Internet]. 2016 [pristupljeno 17.06.2019.];66(2):155-171. doi: https://doi.org/10.1515/acph-2016-0016
IEEE
M.M. GHORAB, M.S. ALSAID, M.S. AL-DOSARI, F.A. RAGAB, A.A. AL-MISHARI i A.N. ALMOQBIL, "Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents", Acta Pharmaceutica, vol.66, br. 2, str. 155-171, 2016. [Online]. doi: https://doi.org/10.1515/acph-2016-0016

Sažetak
As a part of ongoing studies in developing new anticancer agents, a class of structurally novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6-20, acrylamide 21, thiazolidine 22, thiazoles 23-29 and thiophenes 33-35 bearing a biologically active quinoline nucleus were synthesized. The structure of newly synthesized compounds was confirmed on the basis of elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their cytotoxic activity against the breast cancer cell line MCF7. 2,3-Dihydrothiazole-5-carboxamides 27, 25, 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (34), 1,2-dihydroisoquinoline-7-carbonitrile (7), 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide (35), 1,2-dihydroisoquinoline-7-carbonitrile (6), 2-cyano-3-(dimethylamino)-N-quinolin-3-yl)acrylamide (21), 1,2-dihydroisoquinoline-7-carbonitriles (11) and (8) exhibited higher activity (IC50 values of 27-45 μmol L–1), compared to doxorubicin (IC50 47.9 μmol L–1). (Quinolin-3-yl)-1,2-dihydroisoquinoline-7-carbonitrile (12), 2-thioxo-2,3-dihydrothiazole-5-carboxamide (28) and (quinolin-3-yl)-1,2-dihydroisoquinoline-7-carbonitrile (15) show comparable activity to doxorubicin, while (quinolin-3-yl)-1,2-dihydroisoquinoline-7-carbonitrile (9), 2, 3-dihydrothiazole-5-carboxamide (24), thieno [3,4-c] pyridine-4(5H)-one (5), cyclopenta[b]thiophene-3-carboxamide (33) and (quinolin-3-yl)-6-stryl-1,2-dihydroisoquinoline-7-carbonitrile (10) exhibited moderate activity, lower than doxorubicin.

Ključne riječi
quinolines; pyridine; thienopyridine; isoquinoline; acrylamide; thiazole; thiophene; anticancer activity

Hrčak ID: 153877

URI
https://hrcak.srce.hr/153877

Posjeta: 524 *