hrcak mascot   Srce   HID

Original scientific paper
https://doi.org/10.1515/aiht-2016-67-2708

Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study

Damir Sirovina ; Department of Biology, Division of Zoology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Nada Oršolić ; Department of Biology, Division of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Marijana Zovko Končić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Gordana Gregorović ; Department of Biology, Division of Zoology, Faculty of Science, University of Zagreb, Zagreb, Croatia

Fulltext: english, pdf (1 MB) pages 19-24 downloads: 624* cite
APA 6th Edition
Sirovina, D., Oršolić, N., Zovko Končić, M. & Gregorović, G. (2016). Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study. Arhiv za higijenu rada i toksikologiju, 67 (1), 19-24. https://doi.org/10.1515/aiht-2016-67-2708
MLA 8th Edition
Sirovina, Damir, et al. "Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study." Arhiv za higijenu rada i toksikologiju, vol. 67, no. 1, 2016, pp. 19-24. https://doi.org/10.1515/aiht-2016-67-2708. Accessed 15 Apr. 2021.
Chicago 17th Edition
Sirovina, Damir, Nada Oršolić, Marijana Zovko Končić and Gordana Gregorović. "Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study." Arhiv za higijenu rada i toksikologiju 67, no. 1 (2016): 19-24. https://doi.org/10.1515/aiht-2016-67-2708
Harvard
Sirovina, D., et al. (2016). 'Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study', Arhiv za higijenu rada i toksikologiju, 67(1), pp. 19-24. https://doi.org/10.1515/aiht-2016-67-2708
Vancouver
Sirovina D, Oršolić N, Zovko Končić M, Gregorović G. Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study. Arh Hig Rada Toksikol. [Internet]. 2016 [cited 2021 April 15];67(1):19-24. https://doi.org/10.1515/aiht-2016-67-2708
IEEE
D. Sirovina, N. Oršolić, M. Zovko Končić and G. Gregorović, "Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study", Arhiv za higijenu rada i toksikologiju, vol.67, no. 1, pp. 19-24, 2016. [Online]. https://doi.org/10.1515/aiht-2016-67-2708

Abstracts
The effect of naringenin, a flavonoid found in grapefruit, orange, and tomato, on lipid peroxidation and histopathological changes in the liver and kidneys of alloxan-induced diabetic mice were investigated. Two days after alloxan injection (75 mg kg-1, i.v.), naringenin ethanolic solution (0.5 % v/v) was given to mice intraperitoneally (50 mg kg-1 per day) for seven days. Naringenin’s impact on lipid peroxidation was measured by the 2-thiobarbituric acid test and histopathological changes were examined under a light microscope. Naringenin administration resulted in a significant decrease of lipid peroxidation level in liver and kidney tissue, as well as in a decreased number of vacuolated liver cells and degree of vacuolisation. Indications of tissue repair in kidney suggested that amelioration of diabetes-induced renal damage could be achieved over a longer period of time. Findings suggest that naringenin could be considered a dietary supplement in the prevention or treatment of diabetic complications and other diseases connected wih oxidative stress, and gives a hope that it could show similar effects in the treatment of diabetes in humans.

Keywords
diabetes; diabetic kidney; histopathology; lipid peroxidation; liver disease; naringenin

Hrčak ID: 154583

URI
https://hrcak.srce.hr/154583

[croatian]

Visits: 958 *