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Kratko priopćenje
https://doi.org/10.1515/acph-2016-0027

Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid

DAVID CALDERÓN GUZMÁN ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México
NORMA OSNAYA BRIZUELA ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México
MARIBEL ORTÍZ HERRERA ; Laboratorio de Bacteriología Experimental, INP, México City, México
ERNESTINA HERNÁNDEZ GARCÍA ; Laboratorio de Farmacología, INP, México City, México
GERARDO BARRAGÁN MEJÍA ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México
HUGO JUÁREZ OLGUÍN ; Laboratorio de Farmacología, INP, México City, México
ARMANDO VALENZUELA PERAZA ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México
JONAS ATTILUS ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México
NORMA LABRA RUÍZ ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México

Puni tekst: engleski, pdf (326 KB) str. 443-448 preuzimanja: 205* citiraj
APA 6th Edition
GUZMÁN, D.C., BRIZUELA, N.O., HERRERA, M.O., HERNÁNDEZ GARCÍA, E., MEJÍA, G.B., OLGUÍN, H.J., ... RUÍZ, N.L. (2016). Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid. Acta Pharmaceutica, 66 (3), 443-448. https://doi.org/10.1515/acph-2016-0027
MLA 8th Edition
GUZMÁN, DAVID CALDERÓN, et al. "Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid." Acta Pharmaceutica, vol. 66, br. 3, 2016, str. 443-448. https://doi.org/10.1515/acph-2016-0027. Citirano 14.11.2019.
Chicago 17th Edition
GUZMÁN, DAVID CALDERÓN, NORMA OSNAYA BRIZUELA, MARIBEL ORTÍZ HERRERA, ERNESTINA HERNÁNDEZ GARCÍA, GERARDO BARRAGÁN MEJÍA, HUGO JUÁREZ OLGUÍN, ARMANDO VALENZUELA PERAZA, JONAS ATTILUS i NORMA LABRA RUÍZ. "Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid." Acta Pharmaceutica 66, br. 3 (2016): 443-448. https://doi.org/10.1515/acph-2016-0027
Harvard
GUZMÁN, D.C., et al. (2016). 'Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid', Acta Pharmaceutica, 66(3), str. 443-448. https://doi.org/10.1515/acph-2016-0027
Vancouver
GUZMÁN DC, BRIZUELA NO, HERRERA MO, HERNÁNDEZ GARCÍA E, MEJÍA GB, OLGUÍN HJ i sur. Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid. Acta Pharm. [Internet]. 2016 [pristupljeno 14.11.2019.];66(3):443-448. https://doi.org/10.1515/acph-2016-0027
IEEE
D.C. GUZMÁN, et al., "Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid", Acta Pharmaceutica, vol.66, br. 3, str. 443-448, 2016. [Online]. https://doi.org/10.1515/acph-2016-0027

Sažetak
The study tested the hypothesis that cerebrolysin protects the brain from free radicals in rats treated with 3-nitropropionic acid (3-NPA). To address this hypothesis, the levels of dopamine (DA) and some oxidative stress biomarkers were measured after administration of 3-NPA. Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances. Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods. In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased. In addition, calcium and H2O2 levels decreased in the hemispheres of the same group, while GSH increased in cortex. The increased dopamine metabolism due to the administration of cerebrolysin led to increased formation of radical species and oxidative stress, especially when free radicals were generated by 3-NPA.

Ključne riječi
cerebrolysin; dopamine; 3-nitropropionic acid; oxidative stress

Hrčak ID: 154689

URI
https://hrcak.srce.hr/154689

Posjeta: 312 *