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Pregledni rad
Structural chromosome damages - bioindicators of exposure to mutagens
Đ. Horvat
; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
| Puni tekst: hrvatski, pdf (6 MB) | str. 197-203 | citiraj | |
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APA 6th Edition Horvat, Đ. (1979). Strukturalna oštećenja kromosoma i njihovo značenje kao bioindikatora za izloženost mutagenu. Arhiv za higijenu rada i toksikologiju, 30 (2), 197-203. Preuzeto s https://hrcak.srce.hr/161658 MLA 8th Edition Horvat, Đ.. "Strukturalna oštećenja kromosoma i njihovo značenje kao bioindikatora za izloženost mutagenu." Arhiv za higijenu rada i toksikologiju, vol. 30, br. 2, 1979, str. 197-203. https://hrcak.srce.hr/161658. Citirano 28.02.2021. Chicago 17th Edition Horvat, Đ.. "Strukturalna oštećenja kromosoma i njihovo značenje kao bioindikatora za izloženost mutagenu." Arhiv za higijenu rada i toksikologiju 30, br. 2 (1979): 197-203. https://hrcak.srce.hr/161658 Harvard Horvat, Đ. (1979). 'Strukturalna oštećenja kromosoma i njihovo značenje kao bioindikatora za izloženost mutagenu', Arhiv za higijenu rada i toksikologiju, 30(2), str. 197-203. Preuzeto s: https://hrcak.srce.hr/161658 (Datum pristupa: 28.02.2021.) Vancouver Horvat Đ. Strukturalna oštećenja kromosoma i njihovo značenje kao bioindikatora za izloženost mutagenu. Arh Hig Rada Toksikol. [Internet]. 1979 [pristupljeno 28.02.2021.];30(2):197-203. Dostupno na: https://hrcak.srce.hr/161658 IEEE Đ. Horvat, "Strukturalna oštećenja kromosoma i njihovo značenje kao bioindikatora za izloženost mutagenu", Arhiv za higijenu rada i toksikologiju, vol.30, br. 2, str. 197-203, 1979. [Online]. Dostupno na: https://hrcak.srce.hr/161658. [Citirano: 28.02.2021.] |
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Sažetak
Many chemical and physical agents damage normal chromosomal structures in somatic and sex cells ·in man. In the paper are discussed the types of damage according to the phase of the imtermitotic cell cycle. Ionizing radiation damages the genetic mass of the cell in all phases of the intermitotic cycle. Chemical and biological mutagens very often transform the structure of human chromosomes in the course of DNA synthesis. Depending on whether the damage has occurred in the cell phase with a single or a double stranded DNA structural aberrations are classified as chromatid or chromosomal. The usual percentage of spontaneous aberrations. mainly breaks or gaps, is one to five per cent. They occur as a result of the in vitro conditions of cultivation, but to a smaller extent may also appear in viva. Chromosomal damages such as dicentric and ring chromosomes and exchanges are found only rarely or never in healthy nonexposed persons. Their presence is an indication of exposure to mutagens. The persons in whom significant structural chromosome aberrations have been detected should be removed - temporarily or permanently - from the range of the mutagenic agents.
Hrčak ID: 161658
URI
https://hrcak.srce.hr/161658
Moj profil
Srce