Biochemia Medica, Vol. 26 No. 2, 2016.
Pregledni rad
https://doi.org/10.11613/BM.2016.032
Detection of multiple annexin autoantibodies in a patient with recurrent miscarriages, fulminant stroke and seronegative antiphospholipid syndrome.
Philipp Scholz
; Institute for Clinical Chemistry, University of Cologne, Germany
Markus Auler
; Department of Pediatrics and Adolescent Medicine, Experimental Neonatology, University of Cologne, Cologne, Germany
Thomas Benzing
; Department II of Internal Medicine, University of Cologne, Cologne, Germany
Peter Mallman
; Department of Obstetrics and Gynecology, University of Cologne, Cologne, Germany
Thomas Streichert
; Institute for Clinical Chemistry, University of Cologne, Germany
Andreas R. Klatt
; Institute for Clinical Chemistry, University of Cologne, Germany
Sažetak
Anti-phospholipid syndrome (APS) is one of the main causes for recurrent miscarriages. The diagnosis of APS is based on the occurrence of clinical symptoms such as thrombotic events or obstetric complications as well as the detection of antiphospholipid antibodies directed against ß2-glycoprotein I and cardiolipin, or a positive lupus anticoagulant assay. However, there is a subpopulation of patients with clinical symptoms of APS, but the lack of serological markers (seronegative APS). In addition, a large proportion of patients with unexplained recurrent miscarriages exist. These cases may be attributed, at least in part, to a seronegative APS.
The presence of autoantibodies against annexins is potentially associated with APS. Here we used immunoassays and immunoblots to detect autoantibodies directed against annexin A1-5, and A8, respectively, in a patient with a seronegative APS and a history of six recurrent pregnancy losses and fulminant stroke. We found strong IgM isotype antibody reactivity directed against annexin A2 and annexin A8, and moderate to weak IgM isotype antibody reactivity directed against annexin A1, A3, and A5. Further studies will evaluate the diagnostic value of IgM isotype antibodies against annexin A1-A5, and A8 for seronegative APS and recurrent miscarriages.
Ključne riječi
annexin; anti-phospholipid syndrome; anti-phospholipid antibody syndrome; seronegative anti-phospholipid syndrome; recurrent miscarriage
Hrčak ID:
161705
URI
Datum izdavanja:
15.6.2016.
Posjeta: 1.206 *