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Periodicum biologorum, Vol.118 No.2 Lipanj 2016.

Kratko priopćenje
https://doi.org/10.18054/pb.2016.118.2.3700

The trends of the antioxidant drug “U-74389G” on potassium levels during hypoxia reoxygenation injury in rats

Constantinos Tsompos   ORCID icon orcid.org/0000-0003-3469-3127 ; Department of Obstetrics & Gynecology Mesologi County Hospital, Etoloakarnania, Greece
Constantinos Panoulis ; Department of Obstetrics & Gynecology Aretaieion Hospital, Athens University, Attiki, Greece
Konstantinos Toutouzas ; Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
Aggeliki Triantafyllou ; Department of Biologic Chemistry, Athens University Attiki, Greece
George Zografos ; Department of Surgery Ippokrateion General Hospital, Athens University Attiki, Greece
Apostolos Papalois ; Experimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co., Attiki Greece

Puni tekst: engleski, pdf (287 KB) str. 105-110 preuzimanja: 136* citiraj
APA 6th Edition
Tsompos, C., Panoulis, C., Toutouzas, K., Triantafyllou, A., Zografos, G. i Papalois, A. (2016). The trends of the antioxidant drug “U-74389G” on potassium levels during hypoxia reoxygenation injury in rats. Periodicum biologorum, 118 (2), 105-110. https://doi.org/10.18054/pb.2016.118.2.3700
MLA 8th Edition
Tsompos, Constantinos, et al. "The trends of the antioxidant drug “U-74389G” on potassium levels during hypoxia reoxygenation injury in rats." Periodicum biologorum, vol. 118, br. 2, 2016, str. 105-110. https://doi.org/10.18054/pb.2016.118.2.3700. Citirano 13.12.2018.
Chicago 17th Edition
Tsompos, Constantinos, Constantinos Panoulis, Konstantinos Toutouzas, Aggeliki Triantafyllou, George Zografos i Apostolos Papalois. "The trends of the antioxidant drug “U-74389G” on potassium levels during hypoxia reoxygenation injury in rats." Periodicum biologorum 118, br. 2 (2016): 105-110. https://doi.org/10.18054/pb.2016.118.2.3700
Harvard
Tsompos, C., et al. (2016). 'The trends of the antioxidant drug “U-74389G” on potassium levels during hypoxia reoxygenation injury in rats', Periodicum biologorum, 118(2), str. 105-110. doi: https://doi.org/10.18054/pb.2016.118.2.3700
Vancouver
Tsompos C, Panoulis C, Toutouzas K, Triantafyllou A, Zografos G, Papalois A. The trends of the antioxidant drug “U-74389G” on potassium levels during hypoxia reoxygenation injury in rats. Periodicum biologorum [Internet]. 2016 [pristupljeno 13.12.2018.];118(2):105-110. doi: https://doi.org/10.18054/pb.2016.118.2.3700
IEEE
C. Tsompos, C. Panoulis, K. Toutouzas, A. Triantafyllou, G. Zografos i A. Papalois, "The trends of the antioxidant drug “U-74389G” on potassium levels during hypoxia reoxygenation injury in rats", Periodicum biologorum, vol.118, br. 2, str. 105-110, 2016. [Online]. doi: https://doi.org/10.18054/pb.2016.118.2.3700

Sažetak
Background: This experimental study examined the trends of the antioxidant drug “U-74389G”, on a rat model and particularly in a hypoxia – reoxygenation (HR) protocol. The trends of that molecule were studied biochemically using blood mean potassium levels.

Methods: 40 rats of mean weight 231.875 g were used in the study. Potassium (K+) levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D) with administration of the drug U-74389G in groups C and D.

Results: U-74389G administration non significantly decreased the K+ levels by 2.14%+5.06% (p= 0.6730). Reoxygenation time non-significantly increased the K+ levels by 8.66%+4.85% (p= 0.0934). However, U-74389G administration and reoxygenation time together non-significantly increased the K+ levels by 2.07%+3.03% (P= 0.4853).

Conclusions: U-74389G administration, reoxygenation time and their interaction have miscellaneous non significant short – term trends on potassium levels. Perhaps, a longer study time or a higher drug dose may reveal clearer and significant effects.

Ključne riječi
hypoxia; U-74389G; potassium; reoxygenation

Hrčak ID: 162222

URI
https://hrcak.srce.hr/162222

Posjeta: 221 *