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ETHICAL OVERVIEW OF PLACEBO CONTROL IN PSYCHIATRIC RESEARCH - CONCEPTS AND CHALLENGES

Marko Ćurković   ORCID icon orcid.org/0000-0002-4855-2133
Maja Živković
Krešimir Radić
Maja Vilibić
Ivan Ćelić
Dario Bagarić

Puni tekst: engleski, pdf (263 KB) str. 0-125 preuzimanja: 259* citiraj
APA 6th Edition
Ćurković, M., Živković, M., Radić, K., Vilibić, M., Ćelić, I. i Bagarić, D. (2015). ETHICAL OVERVIEW OF PLACEBO CONTROL IN PSYCHIATRIC RESEARCH - CONCEPTS AND CHALLENGES. Psychiatria Danubina, 27 (2), 0-125. Preuzeto s https://hrcak.srce.hr/162384
MLA 8th Edition
Ćurković, Marko, et al. "ETHICAL OVERVIEW OF PLACEBO CONTROL IN PSYCHIATRIC RESEARCH - CONCEPTS AND CHALLENGES." Psychiatria Danubina, vol. 27, br. 2, 2015, str. 0-125. https://hrcak.srce.hr/162384. Citirano 01.04.2020.
Chicago 17th Edition
Ćurković, Marko, Maja Živković, Krešimir Radić, Maja Vilibić, Ivan Ćelić i Dario Bagarić. "ETHICAL OVERVIEW OF PLACEBO CONTROL IN PSYCHIATRIC RESEARCH - CONCEPTS AND CHALLENGES." Psychiatria Danubina 27, br. 2 (2015): 0-125. https://hrcak.srce.hr/162384
Harvard
Ćurković, M., et al. (2015). 'ETHICAL OVERVIEW OF PLACEBO CONTROL IN PSYCHIATRIC RESEARCH - CONCEPTS AND CHALLENGES', Psychiatria Danubina, 27(2), str. 0-125. Preuzeto s: https://hrcak.srce.hr/162384 (Datum pristupa: 01.04.2020.)
Vancouver
Ćurković M, Živković M, Radić K, Vilibić M, Ćelić I, Bagarić D. ETHICAL OVERVIEW OF PLACEBO CONTROL IN PSYCHIATRIC RESEARCH - CONCEPTS AND CHALLENGES. Psychiatria Danubina [Internet]. 2015 [pristupljeno 01.04.2020.];27(2):0-125. Dostupno na: https://hrcak.srce.hr/162384
IEEE
M. Ćurković, M. Živković, K. Radić, M. Vilibić, I. Ćelić i D. Bagarić, "ETHICAL OVERVIEW OF PLACEBO CONTROL IN PSYCHIATRIC RESEARCH - CONCEPTS AND CHALLENGES", Psychiatria Danubina, vol.27, br. 2, str. 0-125, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/162384. [Citirano: 01.04.2020.]

Sažetak
Permissibility of placebo controls in psychiatric research is raising everlasting controversies. The main ethical issue remains:
whether, when, under what conditions, and to what extent is it justifiable to disregard subject’s present (best) interest for the
presumably "greater" ones. In relation to this main ethical concern, two distinct arguments arose: proponents of placebo controls
trials (placebo ortxodoxy) and proponents of active controls trials (active-control orthodoxy). More recently, in new ethical
guidelines, Declaration of Helsinki and International Ethical Guidelines for Biomedical Research Involving Human Subjects, a
"middle way" approach was formulated, acceptable to both sides of the argument, saying placebo controls can be justified under
certain conditions: when and only when, they firstly present undisputed methodological reasoning, and secondly, fulfill certain
ethical considerations – mainly regarding the permissibility of accompanied risks. These ethical evaluations are inevitably
contextual and evoke the need for the principle of proportionality. In scope of recent findings of substantial and progressively
increasing placebo response in psychiatric research, contextual factors are identified and both theoretical and practical challenges
are discussed.

Ključne riječi
clinical research - clinical trials - research ethics – placebo - psychiatry

Hrčak ID: 162384

URI
https://hrcak.srce.hr/162384

Posjeta: 350 *