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DEPRESSION AND SERUM INTERLEUKIN-6 LEVELS IN PATIENTS ON DIALYSIS

Bojan Uglešić ; Department of Psychiatry, University Hospital Centre Split, Split, Croatia
Dragan Ljutić ; Department of Internal Medicine, University Hospital Centre Split, Split, Croatia
Davor Lasić ; Department of Psychiatry, University Hospital Centre Split, Split, Croatia
Ivo Jeličić ; Department of Internal Medicine, University Hospital Centre Split, Split, Croatia
Vitomir Višić ; Psychiatry Hospital Ugljan, Ugljan, Croatia
Trpimir Glavina ; Department of Psychiatry, University Hospital Centre Split, Split, Croatia
Željko Šundov ; Department of Internal Medicine, University Hospital Centre Split, Split, Croatia
Željko Puljiz ; Department of Internal Medicine, University Hospital Centre Split, Split, Croatia
Marija Žuljan Cvitanović ; Department of Psychiatry, University Hospital Centre Split, Split, Croatia
Ana Meter ; Polyclinic

Puni tekst: engleski, pdf (337 KB) str. 0-173 preuzimanja: 173* citiraj
APA 6th Edition
Uglešić, B., Ljutić, D., Lasić, D., Jeličić, I., Višić, V., Glavina, T., ... Meter, A. (2015). DEPRESSION AND SERUM INTERLEUKIN-6 LEVELS IN PATIENTS ON DIALYSIS. Psychiatria Danubina, 27 (2), 0-173. Preuzeto s https://hrcak.srce.hr/162392
MLA 8th Edition
Uglešić, Bojan, et al. "DEPRESSION AND SERUM INTERLEUKIN-6 LEVELS IN PATIENTS ON DIALYSIS." Psychiatria Danubina, vol. 27, br. 2, 2015, str. 0-173. https://hrcak.srce.hr/162392. Citirano 05.04.2020.
Chicago 17th Edition
Uglešić, Bojan, Dragan Ljutić, Davor Lasić, Ivo Jeličić, Vitomir Višić, Trpimir Glavina, Željko Šundov, Željko Puljiz, Marija Žuljan Cvitanović i Ana Meter. "DEPRESSION AND SERUM INTERLEUKIN-6 LEVELS IN PATIENTS ON DIALYSIS." Psychiatria Danubina 27, br. 2 (2015): 0-173. https://hrcak.srce.hr/162392
Harvard
Uglešić, B., et al. (2015). 'DEPRESSION AND SERUM INTERLEUKIN-6 LEVELS IN PATIENTS ON DIALYSIS', Psychiatria Danubina, 27(2), str. 0-173. Preuzeto s: https://hrcak.srce.hr/162392 (Datum pristupa: 05.04.2020.)
Vancouver
Uglešić B, Ljutić D, Lasić D, Jeličić I, Višić V, Glavina T i sur. DEPRESSION AND SERUM INTERLEUKIN-6 LEVELS IN PATIENTS ON DIALYSIS. Psychiatria Danubina [Internet]. 2015 [pristupljeno 05.04.2020.];27(2):0-173. Dostupno na: https://hrcak.srce.hr/162392
IEEE
B. Uglešić, et al., "DEPRESSION AND SERUM INTERLEUKIN-6 LEVELS IN PATIENTS ON DIALYSIS", Psychiatria Danubina, vol.27, br. 2, str. 0-173, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/162392. [Citirano: 05.04.2020.]

Sažetak
Background: Depression is a common psychiatric problem in patients undergoing dialysis. Several studies have been performed
to validate the association between depression and inflammation in haemodialysis patients. The levels of proinflammatory cytokines
are increased in chronic renal failure patients, as in depression. The objective of this study was to compare the incidence of
depression in the patients on dialysis (on hemodialysis /HD/ and on continuous ambulatory peritoneal dialysis /CAPD/), and a
relationship between depression and the presence of inflammation.
Subjects and methods: 88 patients (52 on HD and 36 on CAPD) were enrolled in this study.
Depressive symptoms were measured with the Beck Depression Inventory (BDI). The BDI is a 21-item self-report instrument, and
the elevated symptoms of depression were defined as a BDI score ≥16. HD patients were treated with high-flux polysulphone
biocompatible dialyzers and CAPD patients were treated with usual dwell time (4-6 hours during the day and 8–10 hours at night).
The presence of an inflammatory state was assesded by determinations of plasma interleukin-6 (IL-6) levels.
Results: Depression (BDI ≥ 16) was present in 28.4% of dialysis patients, 35% of patients on hemodialysis (HD) and 18.1% of
patients on continous ambulatory peritoneal dialysis (CAPD). The BDI score was significantly lower in CAPD patients comparing to
HD patients, as well as the levels of albumin, C-reactive protein (CRP) and interleukin-6 (IL-6). IL-6 serum levels were similar in
patients with depression and patients without depression in the whole group, as in HD patients. In CAPD patients without depression
IL-6 levels were significantly lower.
Conclusions: The prevalence of depression was higher in HD comparing to CAPD patients. Although IL-6 level was higher in
HD compared to CAPD patients, the relationship between depression and presence of inflammation parametars were observed in
CAPD, but not in HD patients.

Ključne riječi
depression - interleukin-6 – hemodialysis - continuous ambulatory peritoneal dialysis

Hrčak ID: 162392

URI
https://hrcak.srce.hr/162392

Posjeta: 270 *