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IMMUNE RESPONSES OF A MOUSE TO BEE VENOM

Stipica Ćurić ; Department of Pathology
Boris Krsnik ; Department of Zoohygiene
Tomislav Balenović ; Department of Animal Breeding and Husbandry
Ivica Valpović ; Department of Biology
Đuro Sulimanović ; Department for Biology and Pathology of Fish and Bees, Veterinary Faculty, University of Zagreb, Republic of Croatia
Nada Oršolić ; Department of Animal Physiology, Faculty of Science, University of Zagreb, Republic of Croatia
Ivan Bašić ; Department of Animal Physiology, Faculty of Science, University of Zagreb, Republic of Croatia

Sažetak

The effect of honeybee venom on humoral (gammaglobulin and total protein levels) and cellular immune responses (weight and cellularity of spleen and lymph nodes) was tested in CBA mice. Bee venom was injected subcutaneously into the left footpad at a dose of 0.15,0.30, or 0.60 mg per mouse, respectively. Mean gammaglobulina and total protein values were significantly elevated (P <0.05) in mice treated with 0.15 mg or 0.30 mg of bee venom, respectively, compared to those recorded in nontreated controls. The weight of the left popliteal lymph node (LPLN) was significantly higher (P<0.01) in mice given 0.30 mg or 0.60 mg of bee venom than that of the controls. The cellularity of LPLN in bee venom-treated mice was much greater (P<0.05; <0.01) when compared to the control values. However, no differences in weight and cellualarity of the popliteal lymph node were noticed in mice treated identically with propolis, used as an antigen. There were no differences in weight or cellularity of spleen between treated and control mice.

Ključne riječi

Hrčak ID:

162574

URI

https://hrcak.srce.hr/162574

Datum izdavanja:

20.5.1993.

Podaci na drugim jezicima: hrvatski

Posjeta: 656 *